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Mashup Score: 3Gut microbiota–specific IgA+ B cells traffic to the CNS in active multiple sclerosis - 3 year(s) ago
Multiple sclerosis (MS) is associated with production of oligoclonal IgG antibodies within the central nervous system (CNS), but less is known about the status of IgA-producing cells. Pröbstel et al. detected clonally expanded IgA+ cells in cerebrospinal fluid and tissue adjacent to areas of active MS-associated demyelination. Recombinant IgA antibodies assembled from the cloned antibody genes…
Source: Science ImmunologyCategories: Gastroenterology, Latest HeadlinesTweet
#GastroEdPick Gut microbiota-specific IgA+ B cells traffic to CNS in active multiple sclerosis - IgA could be potential biomarker & IgA-producing cells as a possible therapeutic target ? #gutbrainaxis @SciImmunology https://t.co/imBR4H5jM5