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Mashup Score: 0
Background/Purpose Little is known about long-term clinical outcomes or urate-lowering (ULT) therapy use following pegloticase discontinuation. We examined ULT use, serum urate (SU), inflammatory biomarkers, and renal function following pegloticase discontinuation. Methods We conducted a retrospective analysis of gout patients who discontinued pegloticase using the Rheumatology Informatics System for Effectiveness (RISE) registry from 1/2016 to 6/2022. We defined discontinuation as a gap ≥ 12 weeks after last infusion. We examined outcomes beginning two weeks after last dose and identified ULT therapy following pegloticase discontinuation. We evaluated changes in lab values (SU, eGFR, CRP and ESR), comparing on- treatment (≤ 15 days of the second pegloticase dose) to post-treatment. Results Of the 375 gout patients discontinuing pegloticase, median (IQR) laboratory changes following discontinuation were: SU: +2.4 mg/dL (0.0,6.3); eGFR: -1.9 mL/min (− 8.7,3.7); CRP: -0.8 mg/L (-12.8,0.0
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Mashup Score: 2Virtual Events | KRYSTEXXA (pegloticase) - 14 day(s) ago
Join live, interactive discussions with gout specialists and real KRYSTEXXA patients who can answer your most pressing questions. See safety info.
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Mashup Score: 0
Alkaline water significantly reduced VAS pain scores among patients with gout.
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Mashup Score: 0
Patients with gout who had poor health literacy were more likely to experience ≥ 2 flares within the previous 12 months.
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Mashup Score: 22The clinical benefits of sodium–glucose cotransporter type 2 inhibitors in people with gout - 25 day(s) ago
Nature Reviews Rheumatology – Gout is associated with various cardiometabolic–renal comorbidities that increase the risk of mortality. Sodium–glucose cotransporter type 2 (SGLT2)…
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Mashup Score: 1If You Have Gout, You May Benefit From More Exercise - 1 month(s) ago
Learn about the benefits of exercise for gout, including fewer flare-ups and better joint health.
Source: www.henryford.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 4SGLT2 Inhibitors Could Play a Role in Treating Gout - 1 month(s) ago
A new review considers how SGLT2 inhibitors like dapagliflozin and empagliflozin have been shown to clinically improve gout while reducing its cardiometabolic and renal comorbidities.
Source: www.hcplive.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 35The clinical benefits of sodium–glucose cotransporter type 2 inhibitors in people with gout - 1 month(s) ago
Nature Reviews Rheumatology – Gout is associated with various cardiometabolic–renal comorbidities that increase the risk of mortality. Sodium–glucose cotransporter type 2 (SGLT2)…
Source: www.nature.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 0
Patients with higher baseline serum urate levels demonstrate increased recurrent gout hospitalization rates and subsequent risk for flare over 10 years of follow-up, according to data published in JAMA. The findings suggest that most gout flares are “potentially preventable at the population level” with the achievement of serum urate targets of less than 6 or 5 mg/dL, Hyon K. Choi,
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Mashup Score: 1Clinical Quiz: ACR Guideline for the Management of Gout - 1 month(s) ago
Test your knowledge of the ACR’s guideline for the management of gout with this quiz!
Source: www.hcplive.comCategories: General Medicine News, General HCPsTweet
Of 375 #Gout pts D/C pegloticase after a median of 8 infusions (taken 112days (max 1,240d). Only 73% had SUA < 6 during pegloticase. After D/C 84% went on ULT (63% allopurinol; 34% febuxostat; after mean 92d); after ≥ 30 days), 51% achieved SUA < 6 https://t.co/unkvt1whrs https://t.co/DgVpBgKXcm