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Mashup Score: 2Modern subcutaneous implantable defibrillator therapy in patients with cardiomyopathies and channelopathies: data from a large multicentre registry - 9 month(s) ago
AbstractAims. Patients with cardiomyopathies and channelopathies are usually younger and have a predominantly arrhythmia-related prognosis; they have nearly nor
Source: academic.oup.comCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 0A broad genetic test saved one newborn's life. Research suggests it could help millions of others - 9 month(s) ago
A recent study showed that tests for sick newborns that look at their full genetic blueprints are nearly twice as good at finding genetic problems as narrower, more commonly used tests.
Source: apnews.comCategories: Future of Medicine, Latest HeadlinesTweet-
A broad #genetics test saved one newborn’s life. Research suggests it could help millions of others - whole #genomesequencing | #diagnostics https://t.co/ULy5H4cWSQ
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Mashup Score: 0Vorasidenib in IDH1- or IDH2-Mutant Grade 2 Glioma - The ASCO Post - 9 month(s) ago
As reported in The New England Journal of Medicine by Ingo K. Mellinghoff, MD, FACP, and colleagues, the phase III INDIGO trial has shown that vorasidenib, an oral brain-penetrant inhibitor of mutant IDH1 and IDH2 enzymes, significantly improved progression-free survival vs placebo in patients with IDH1 – or IDH2 -mutant residual or recurrent grade 2 glioma who had received no prior treatment other than surgery. Ingo K. Mellinghoff, MD, FACP In the double-blind trial, 331 patients from sites in 10
Source: ascopost.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Vorasidenib in IDH1- or IDH2-Mutant Grade 2 Glioma https://t.co/94FlBtQB83 #btsm #glioma #oncology #genetics
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Mashup Score: 29Gene Transfer Offers Longevity Hope - Neuroscience News - 9 month(s) ago
In a pioneering study, researchers transferred a longevity gene from the remarkably age-resistant naked mole rat to mice, leading to an extended lifespan for the mice.
Source: neurosciencenews.comCategories: Latest Headlines, NeurologyTweet-
Unlocking the secrets of aging. Researchers have transferred a longevity gene from naked mole rats to mice, gifting them with extended life and health. Could this be a step toward longer human lives? https://t.co/3xoCs5rwzf #genetics #longevity 1/2 https://t.co/5FY3n0esom
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Mashup Score: 2
AML is distinguished by the rapid division and metastasis of immature leukemia stem cells. More than 50% of patients who are treated for leukemia relapse, and the 5-year survival rate is 30%. Figuring out how to destroy these cells may be crucial to effectively treating the disease. TET2 deficiencies cooperate with leukemia-related oncoproteins resulting from chromosomal abnormalities or gene mutations to drive the development of leukemia and enhance the malignant stem cells’ ability to divide and
Source: ascopost.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Understanding How TET2 Gene Deficiency May Fuel Development of AML https://t.co/uUrwknmWbt #leusm #leukemia #hematology #genetics
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Mashup Score: 0Researchers May Have Identified Several New Breast Cancer Susceptibility Genes - The ASCO Post - 9 month(s) ago
Currently, genetic tests for breast cancer consider a few genes such as BRCA1, BRCA2, and PALB2. However, these genes may explain only a minority of the genetic risk, suggesting more genes remain to be identified. In this large-scale international collaborative study, the researchers analyzed genetic changes across all genes in 26,000 patients with breast cancer and 217,000 controls. The researchers found evidence for at least four new genes potentially predictive of the risk of breast cancer. The
Source: ascopost.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Researchers May Have Identified Several New Breast Cancer Susceptibility Genes https://t.co/MNPhneVH7g #bcsm #breastcancer #genetics #oncology
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Mashup Score: 2Therapeutic Implications of DNA Repair Discoveries in Patients With Homologous Recombination Deficiencies - The ASCO Post - 9 month(s) ago
Once DNA is damaged by toxins, radiation, or normal cell division, human cells must continually fix DNA breaks to survive. When cells are unable to repair their DNA effectively, mutations can occur that lead to cancer. Most cells rely on homologous recombination (HR), which uses proteins called BRCA1 and BRCA2 for accurate DNA repair. Those born with BRCA gene mutations, however, often develop breast cancer and ovarian cancer. BRCA mutations and HR-related issues have recently been found to occur in
Source: ascopost.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Therapeutic Implications of DNA Repair Discoveries in Patients With Homologous Recombination Deficiencies https://t.co/CnQaKUyYLx #cancer #genetics
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Mashup Score: 5Targeting IDH in Low-Grade Glioma | NEJM - 9 month(s) ago
Editorial from The New England Journal of Medicine — Targeting IDH in Low-Grade Glioma
Source: www.nejm.orgCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Read the science behind the study in a new editorial, “Targeting IDH in Low-Grade Glioma” by Elizabeth B. Claus, M.D., Ph.D., and @roelverhaak, Ph.D.: https://t.co/9u8nq5ydAF 15/15 #oncology
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Grade 2 glioma affects approximately 30,000 adults in the United States: the mean age at diagnosis is 41 years. Treatment options and survival times have not changed substantially over the past 40 years. Science behind the Study: https://t.co/9u8nq5ydAF 1/15 #genetics
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Mashup Score: 0Alcohol and Cancer Risk Fact Sheet - 9 month(s) ago
A fact sheet that summarizes the evidence linking alcohol consumption to the risk of various cancers. Includes information about factors that affect the risk of alcohol-associated cancers.
Source: www.cancer.govCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
#DYK: A person’s risk of alcohol-related cancers is influenced by their genes, specifically the genes that encode enzymes involved in metabolizing #alcohol? Read more on how #genetics affect the risk of alcohol-related cancers: https://t.co/MswTH4MNXt https://t.co/Tx02jqZrPA
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Mashup Score: 1Genome-wide prediction of disease variant effects with a deep protein language model - 9 month(s) ago
Nature Genetics – A modified framework leveraging a protein language model (ESM1b) is used to predict all possible 450 million missense variant effects in the human genome and shows potential for…
Source: www.nature.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
THIS ROCKS: #Genome-wide prediction of #disease variant effects with a deep protein language model https://t.co/X6IwVMRHvv #Genetics #Genomics #ClinVar #HGMD Advancing #variant effect prediction using protein language models https://t.co/KuI085HUJ4 #pathogenic #SNV/#SNP… https://t.co/lT0TnZv0EK https://t.co/cwI5AWqxqb
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Long-term outcomes of S-ICD in patients with channelopathies and cardiomyopathies 👉 https://t.co/fqBKFeg5wA @EuropaceEiC @GiulioConte9 @Dominik_Linz @FraSantoroMD @AndyZhangMD @marcovitoloMD #genetics #Europace #S-ICD https://t.co/q7OrG9CMtc