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Mashup Score: 2Significance and potential role of eosinophils in non-cystic fibrosis bronchiectasis - 2 year(s) ago
Bronchiectasis is a complex and heterogeneous disease caused by a myriad of pulmonary and extrapulmonary aetiologies. Bronchiectasis has a predominantly neutrophilic inflammatory profile, however, eosinophilic inflammation has also been documented in both the airways and systemic circulation. Various diseases (e.g. asthma, allergic bronchopulmonary aspergillosis, chronic rhinosinusitis with nasal…
Categories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 1Cystic Fibrosis: Highly Effective Targeted Therapeutics and the Impact on Sex and Racial Disparities - PubMed - 2 year(s) ago
People with Cystic Fibrosis (CF) are living longer and healthier lives due in part to new therapies, called Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulators. However, disparities in outcomes still exist, with females demonstrating a shorter life expectancy than males; this is op …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0
The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel and the epithelial Na+ channel (ENaC) play essential roles in transepithelial ion and fluid transport in numerous epithelial tissues. Inhibitors of both channels have been important tools for defining their physi …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 1
TOT fills a critical gap in preparing people with CF for shared decision-making about LTx and may serve as a model for educational tools for other preference-sensitive decisions.
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0Protocol for establishing a core outcome set for evaluation in studies of pulmonary exacerbations in people with cystic fibrosis - PubMed - 2 year(s) ago
National mutual ethics scheme approval has been provided by the Child and Adolescent Health Service Human Research Ethics Committee (RGS 4926). Results will be disseminated via consumer and research networks and peer-reviewed publications. This study is registered with the Core Outcome Measures in E …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0Non-respiratory health-related quality of life in people with cystic fibrosis receiving elexacaftor/tezacaftor/ivacaftor - PubMed - 2 year(s) ago
Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was shown to be safe and efficacious in people with cystic fibrosis (CF) heterozygous for F508del and a minimal function mutation (F/MF) or homozygous for F508del (F/F) in two pivotal Phase 3 trials, significantly improving percentage predicted forced e …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0Beyond borders: cystic fibrosis survival between Australia, Canada, France and New Zealand - PubMed - 2 year(s) ago
We observed significantly higher survival in France compared with countries with single-payer healthcare systems. The median age of survival in France exceeded 60 years of age despite having the highest proportion of underweight patients which may be due to differences in availability of transplant.
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0
Case 26-2022: A 48-Year-Old Woman with Cystic Lung Disease
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0Frailty predicts outcomes in cystic fibrosis patients listed for lung transplantation - PubMed - 2 year(s) ago
In CF patients listed for LT, FI risk stratification was significantly associated with waitlist and post-LT outcomes. Studying frailty in young populations with advanced disease can provide insights on how frailty and deficit accumulation impacts survival.
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 0Real-world Associations of US Cystic Fibrosis Newborn Screening Programs With Nutritional and Pulmonary Outcomes - PubMed - 2 year(s) ago
NBS for CF in the US was associated with improved nutritional status up to age 10 years, a more rapid increase in lung function, and delayed chronic P aeruginosa infection. In the future, as highly effective modulator therapies become available for infants with CF, NBS will allow for presymptomatic …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet
In Press! Significance and #potential #role of #eosinophils in #non- #cystic #fibrosis #bronchiectasis https://t.co/to8i69TvQD