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Mashup Score: 1COX-2 Inhibitors Decrease Expression of PD-L1 in Colon Tumors and Increase the Influx of Type I Tumor-infiltrating Lymphocytes - 1 month(s) ago
Nonsteroidal anti-inflammatories (NSAID) are an essential component of any combination chemoprevention of colon cancer. We show NSAID treatment reduces PD-L1 expression on intestinal tumor cells. NSAID regulation of PD-L1 is dependent on COX-2 expression. These data underscore an important immunologic mechanism of action for NSAID in colon cancer prevention.
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
Read the article by the recipients of the Cancer Prevention Research Award for Outstanding Journal Article, Denise Cecil et al.— COX-2 regulates PD-L1 in #coloncancer. https://t.co/quyZZqjLub @AACR #AACR24 https://t.co/AYGq0HyfAK