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Mashup Score: 1Moving Forward Liquid Biopsy in Early Liver Cancer Detection - 1 year(s) ago
Summary:. Early cancer detection is an attractive and promising application for liquid biopsy that might revolutionize cancer screenings. In this issue of Cancer Discovery, Foda and colleagues expand the potential utility of a machine learning fragmentome-based model, called DELFI, for detecting liver cancer in high-risk patients.See related article by Foda et al., p. 616 (5).
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 4Advancements in the treatment of biliary tract cancers - 1 year(s) ago
Ghassan Abou-Alfa, MD, MBA, Memorial Sloan Kettering Cancer Center, New York, NY, comments on the latest developments in the management…
Source: VJOncologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Points on #cfDNA at @ASCO #GIASCO2023 by @MSKCancerCenter @MSK_DeptOfMed @GABOUALFA on @VJOncology https://t.co/l9lQucvyqW
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Mashup Score: 2Urine cfDNA Multi-Omics to Detect Molecular Residual Disease and Predict Survival in Patients With Bladder Cancer - 1 year(s) ago
Read it now on PracticeUpdate.com
Source: PracticeUpdateCategories: Hem/Oncs, Latest HeadlinesTweet-
Urine #cfDNA-Detects Molecular Residual Disease with 87% sensitivity (n=74, 78% muscle-invasive) & Predicts Survival in #bladdercancer-work by @aadel_chaudhuri-commentary @ClintonTim-promising data & emerging role in bladder preservation https://t.co/3GzrTndZhm @practiceupdate
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Mashup Score: 1Nucleosome patterns in circulating tumor DNA reveal transcriptional regulation of advanced prostate cancer phenotypes - 1 year(s) ago
Abstract. Advanced prostate cancers comprise distinct phenotypes, but tumor classification remains clinically challenging. Here, we harnessed circulating tumor DNA (ctDNA) to study tumor phenotypes by ascertaining nucleosome positioning patterns associated with transcription regulation. We sequenced plasma ctDNA whole genomes from patient-derived xenografts representing a spectrum of androgen…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
#ICYMI: Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced #ProstateCancer Phenotypes, by @Navonilde, Robert Patton, Peter Nelson, @GavinHa et al. https://t.co/zbzJHCpru6 @fredhutch #LiquidBiopsy #cfDNA #ctDNA https://t.co/NIkjOGgOwV
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Mashup Score: 8Nucleosome patterns in circulating tumor DNA reveal transcriptional regulation of advanced prostate cancer phenotypes - 1 year(s) ago
Abstract. Advanced prostate cancers comprise distinct phenotypes, but tumor classification remains clinically challenging. Here, we harnessed circulating tumor DNA (ctDNA) to study tumor phenotypes by ascertaining nucleosome positioning patterns associated with transcription regulation. We sequenced plasma ctDNA whole genomes from patient-derived xenografts representing a spectrum of androgen…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced #ProstateCancer Phenotypes, by @Navonilde, Robert Patton, Peter Nelson, @GavinHa et al. https://t.co/xvrVQGqJab @fredhutch #LiquidBiopsy #cfDNA #ctDNA https://t.co/I1kMfGixAg
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Mashup Score: 6Detecting liver cancer using cell-free DNA fragmentomes - 1 year(s) ago
Abstract. Liver cancer is a major cause of cancer mortality worldwide. Screening individuals at high-risk, including those with cirrhosis and viral hepatitis, provides an avenue for improved survival, but current screening methods are inadequate. In this study, we used whole-genome cell-free DNA fragmentome analyses to evaluate 724 individuals from the US, EU, or Hong Kong with hepatocellular…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Detecting #LiverCancer Using Cell-free DNA Fragmentomes, by @ZHFodaMDPhD, @av_annapragada, Amy Kim, @velculescu et al. https://t.co/UU4wjYQiZE @hopkinskimmel @HopkinsMedicine #LiquidBiopsy #cfDNA https://t.co/QKDwRm4aqe
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Mashup Score: 0
Jamshidi et al. compare several approaches for circulating cell-free DNA (cfDNA)-based multi-cancer early detection (MCED) tests. A whole-genome methylation-based approach has the best performance among those evaluated. In addition, they define a metric—clinical limit of detection (LOD)—based on tumor fraction to enable future comparison of cfDNA-based tests.
Source: Cancer CellCategories: Hem/Oncs, Latest HeadlinesTweet-
New #cfDNA paper: 1) Clinical LOD a useful benchmark to assess cfDNA-based test performance 2) cTAF accounts for cfDNA cancer signal variation across cancer types and stages 3) cfDNA methylation most promising #genomic feature for cancer signal detection https://t.co/noOh2qlbZk
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Mashup Score: 9ESMO Advanced Course on Biomarkers for Precision Cancer Medicine - 2 year(s) ago
25-26 November 2022 – Zurich, Switzerland
Source: www.esmo.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Registration open for the ESMO Advanced Course on #Biomarkers for #PrecisionMedicine taking place in Zurich on 25-26 Nov 2022. 🔗 https://t.co/ZbRVhIPjk0 #precisiononcology #cfDNA @SamraTurajlic @BenWestphalen @aftimosp @UmbertoMalapel1 @TarazonaNoelia https://t.co/kZ7ubLls2Q
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Mashup Score: 1Residual ctDNA after treatment predicts early relapse in patients with early-stage non-small cell lung cancer - 2 year(s) ago
Identification of residual disease in patients with localized non-small cell lung cancer (NSCLC) following treatment with curative intent holds promis…
Source: www.sciencedirect.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Residual #ctDNA after #Treatment predicts early relapse in patients with early-stage #NonSmallCell #LungCancer: 1⃣This may help identify patients who need further therapeutic intervention!👇 https://t.co/4eUNuXx9Do #LiquidBiopsy #cfDNA https://t.co/kXSFq6yIxo
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Mashup Score: 3Inferring gene expression from cell-free DNA fragmentation profiles - Nature Biotechnology - 2 year(s) ago
EPIC-seq predicts expression of individual genes from cell-free DNA.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
SCI members @max_diehn @AshAlizadeh & colleagues developed EPICSeq, a transformative new #liquidbiopsy technique to non invasively capture tissue phenotype from blood #cfDNA. https://t.co/irQ1Qy6rmv #DLBCL #NSCLC @mohamshah https://t.co/e1dUfiqqdf
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In the Spotlight— Moving forward liquid biopsy in early #livercancer detection, by @ChristianRolfo and @Al3ssandroRusso. https://t.co/G6orwEMuz1 @TischCancer @MountSinaiNYC #LiquidBiopsy #cfDNA https://t.co/Ia8W9TiLbD