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Mashup Score: 28Sequential maturation of stimulus-specific adaptation in the mouse lemniscal auditory system - 4 month(s) ago
During adolescence, cerebral cortex flexibly and adaptively orchestrates the refinement of neural responses to surprising sounds.
Source: www.science.orgCategories: General Medicine News, General NewsTweet
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Mashup Score: 7Close-packed dual-color micro-LEDs enable cortical-layer-specific bidirectional in vivo optogenetic electrophysiology - 4 month(s) ago
Optogenetics promises to manipulate the brain circuitry by exciting or inhibiting the same neurons via different colors of light (i.e., bidirectionali…
Source: www.sciencedirect.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 29Minute-scale oscillatory sequences in medial entorhinal cortex - 5 month(s) ago
Nature – Neural population activity in the medial entorhinal cortex of mice can be organized into ultraslow oscillatory sequences, with periods extending up to the minute range.
Source: www.nature.comCategories: General Medicine News, General NewsTweet
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Mashup Score: 24Scientists uncover secrets of brain development: Extensive neural migration continues after birth - 5 month(s) ago
The human brain continues to be built after we are born for far longer than previously recognized, suggests research by Shawn Sorrells, assistant professor of neuroscience in the Kenneth P. Dietrich School …
Source: medicalxpress.comCategories: General Medicine News, General NewsTweet
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Mashup Score: 10Integrative single-cell RNA-seq analysis of vascularized cerebral organoids - BMC Biology - 5 month(s) ago
Background Cerebral organoids are three-dimensional in vitro cultured brains that mimic the function and structure of the human brain. One of the major challenges for cerebral organoids is the lack of functional vasculature. Without perfusable vessels, oxygen and nutrient supplies may be insufficient for long-term culture, hindering the investigation of the neurovascular interactions. Recently, several strategies for the vascularization of human cerebral organoids have been reported. However, the generalizable trends and variability among different strategies are unclear due to the lack of a comprehensive characterization and comparison of these vascularization strategies. In this study, we aimed to explore the effect of different vascularization strategies on the nervous system and vasculature in human cerebral organoids. Results We integrated single-cell RNA sequencing data of multiple vascularized and vascular organoids and fetal brains from publicly available datasets and assessed
Source: bmcbiol.biomedcentral.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 3WaveSep: A Flexible Wavelet-Based Approach for Source Separation - 5 month(s) ago
The separation of signal contributions from paramagnetic and diamagnetic susceptibility sources in MRI has important implications for understanding the biological functions and health conditions of the brain. However, general and flexible deep-learning-based tools…
Source: link.springer.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 17A global view of aging and Alzheimer’s pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains - 5 month(s) ago
Nature Genetics – Single-cell transcriptomes and single-cell chromatin accessibility profiles generated using EasySci provide a global view of aging and Alzheimer’s pathogenesis-associated…
Source: www.nature.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 32Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology - 5 month(s) ago
Martinos Center for Biomedical Imaging, MGH and Harvard Medical School, Charlestown, MA, USA Centre for Medical Image Computing, University College London, London, UK Computer Science and Artificial Intelligence Laboratory, MIT, MA, USA Biomedical Imaging Group, Universitat Politècnica de Catalunya, Spain BioRepository and Integrated Neuropathology (BRaIN) laboratory and Precision Neuropathology Core, UW School of Medicine, WA, USA Massachusetts Alzheimer Disease Research Center, MGH and Harvard Medical
Source: elifesciences.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 15CNS tumor stroma transcriptomics identify perivascular fibroblasts as predictors of immunotherapy resistance in glioblastoma patients - 5 month(s) ago
npj Genomic Medicine – CNS tumor stroma transcriptomics identify perivascular fibroblasts as predictors of immunotherapy resistance in glioblastoma patients
Source: www.nature.comCategories: General Medicine News, General NewsTweet
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Mashup Score: 6Developmental changes in neonatal hemodynamics during tactile stimulation using whole-head functional near-infrared spectroscopy - 5 month(s) ago
Neural-activity-associated hemodynamic changes have been used to noninvasively measure brain function in the early developmental stages. However, the …
Source: www.sciencedirect.comCategories: General Medicine News, General HCPsTweet
How the #brain learns to deal with surprises @unibasel @ScienceAdvances https://t.co/HUSGNzd5cR https://t.co/upztazbcoC