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Mashup Score: 1Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial - Critical Care - 2 year(s) ago
Background Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia. Methods CARDEA was a phase 2, randomized, double-blind, placebo-controlled trial evaluating the addition of Auxora, a CRAC channel inhibitor, to corticosteroids and standard of care in…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet
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Mashup Score: 10
Background Increasing evidence indicates the potential benefits of restricted fluid management in critically ill patients. Evidence lacks on the optimal fluid management strategy for invasively ventilated COVID-19 patients. We hypothesized that the cumulative fluid balance would affect the successful liberation of invasive ventilation in COVID-19 patients with acute respiratory distress syndrome…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess The potential benefits of restricted #fluid management in critically ill patients https://t.co/rM6FWlQTsk @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #Ventilation #ARDS #respiratory_failure https://t.co/tydUqrfAAx
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Mashup Score: 0Impairment of neutrophil functions and homeostasis in COVID-19 patients: association with disease severity - Critical Care - 2 year(s) ago
Background A dysregulated immune response is emerging as a key feature of critical illness in COVID-19. Neutrophils are key components of early innate immunity that, if not tightly regulated, contribute to uncontrolled systemic inflammation. We sought to decipher the role of neutrophil phenotypes, functions, and homeostasis in COVID-19 disease severity and outcome. Methods By using flow…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess #COVID19: #neutrophil #phenotypes, functions, and #homeostasis in disease severity and outcome https://t.co/SB81aAoIlb @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #SarsCov2 #Oxidative_burst #Angiogenic #Vascular #Inflammation https://t.co/zkMIdDCtmw
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Mashup Score: 2Effect of erythromycin on mortality and the host response in critically ill patients with sepsis: a target trial emulation - Critical Care - 2 year(s) ago
Background Immunomodulatory therapies that improve the outcome of sepsis are not available. We sought to determine whether treatment of critically ill patients with sepsis with low-dose erythromycin—a macrolide antibiotic with broad immunomodulatory effects—decreased mortality and ameliorated underlying disease pathophysiology. Methods We conducted a target trial emulation, comparing patients…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess Does low-dose #erythromycin decrease mortality & improve outcome in #sepsis? https://t.co/HfwBWSDnBL @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #Immunomodulation #Macrolides https://t.co/Qgz1lZCPQU
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Mashup Score: 2
Background Extracorporeal membrane oxygenation (ECMO) has been used extensively for coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS). Reports early in the pandemic suggested that mortality in patients with COVID-19 receiving ECMO was comparable to non-COVID-19-related ARDS. However, subsequent reports suggested that mortality appeared to be increasing over…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess #ECMO during #COVID19 pandemics: changes in #mortality over time and #risk_factors for poor outcomes https://t.co/ueWjmqzZ1p @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #Meta_analysis #SarsCov2 https://t.co/TrKNEeVSLp
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Mashup Score: 2Venous return and mean systemic filling pressure: physiology and clinical applications - Critical Care - 2 year(s) ago
Venous return is the flow of blood from the systemic venous network towards the right heart. At steady state, venous return equals cardiac output, as the venous and arterial systems operate in series. However, unlike the arterial one, the venous network is a capacitive system with a high compliance. It includes a part of unstressed blood, which is a reservoir that can be recruited via sympathetic…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess #VenousReturn: how does #Guyton’s #physiology help understand the effects on #CardiacOutput of common treatments used in critically ill patient? https://t.co/Kyx7qmrbF7 @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #Norepinephrine #lung #heart #FluidTherapy https://t.co/eKgSAFlaGv
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Mashup Score: 0
Background Medical nutrition therapy may be associated with clinical outcomes in critically ill patients with prolonged intensive care unit (ICU) stay. We wanted to assess nutrition practices in European intensive care units (ICU) and their importance for clinical outcomes. Methods Prospective multinational cohort study in patients staying in ICU ≥ 5 days with outcome recorded until day 90….
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess In patients staying in ICU ≥ 5 days, early moderate daily #calorie and #protein intakes were associated with improved clinical outcomes https://t.co/4Ch4FVY6a0 @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #nutrition #Weaning #mechanical_ventilation https://t.co/yHxiJR8IOE
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Mashup Score: 4TTCOV19: timing of tracheotomy in SARS-CoV-2-infected patients: a multicentre, single-blinded, randomized, controlled trial - Critical Care - 2 year(s) ago
Background Critically ill COVID-19 patients may develop acute respiratory distress syndrome and the need for respiratory support, including mechanical ventilation in the intensive care unit. Previous observational studies have suggested early tracheotomy to be advantageous. The aim of this parallel, multicentre, single-blinded, randomized controlled trial was to evaluate the optimal timing of…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess #COVID19: What’s the optimal timing for #tracheotomy? https://t.co/0RC1CPE7UI @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #SARS_CoV_2 #pandemics #Mechanical_ventilation https://t.co/4wAcQu616R
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Mashup Score: 1Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis - Critical Care - 2 year(s) ago
Background The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patients with moderate-to-severe ARDS the impact of early use of NMBAs on 90-day mortality, through propensity score (PS) matching analysis. Methods We analyzed a convenience sample of…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OA #COVID19: the impact of early use of #neuromuscular_blocking_agents on 90-day #mortality https://t.co/pJzkT46JwW #FOAMed #FOAMcc #BMC @ISICEM @jlvincen #ICU #SARS_CoV_2 #pandemics #NMBAs #Mechanical_ventilation https://t.co/EKhniahOnt
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Mashup Score: 0
Background Sarcopenia is defined as age-related loss of muscle mass, strength, and/or function in the context of aging. Mechanical ventilation (MV) is one of the most frequently used critical care technologies in critically ill patients. The prevalence of preexisting sarcopenia and the clinical impact of its prognostic value on patients with MV are unclear. This review sought to identify the…
Source: BioMed CentralCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OpenAccess #Prevalence & prognostic value of preexisting #sarcopenia on mechanically ventilated patients’ #outcome https://t.co/azyVR8hkPX @jlvincen @ISICEM #FOAMed #FOAMcc #BMC #ICU #muscle #ventilation #mortality https://t.co/wiZWt64vTy
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#CritCare #OpenAccess EDITOR’S PICK https://t.co/Kh89E7c0Oa #AUXORA + #CORTICOSTEROIDS: A NEW STANDARD OF CARE IN SEVERE #COVID_19 #PNEUMONIA? #FOAMed #FOAMcc #BMC #ICU #lung #respiratory_failure #ARDS #cytokine #calcium_channel #immunology #Sars_CoV2 @jlvincen @ISICEM https://t.co/O7goK0hhvs