• Mashup Score: 2
    Volume 22 Issue 1, January 2022 - 2 year(s) ago

    Volume 22 Issue 1, January 2022

    Source: www.nature.com
    Categories: Hem/Onc News and Journals, Latest Headlines
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      NatureRevCancer

      Happy new year everybody! Start 2022 with browsing our Jan issue: cancer-focused Reviews on targeting #transcription cycles, overcoming #TGFβ-mediated immune evasion, and manipulating #apoptosis using #BH3-mimetic drugs! 💌 https://t.co/bhA8FyE9TB @natrescancer #CancerTherapy https://t.co/rJGs8NFy9N

  • Mashup Score: 25
    The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs - Nature Reviews Cancer - 3 year(s) ago

    BH3-mimetic drugs have been designed to directly induce apoptosis in cancer cells by targeting prosurvival BCL-2 family proteins. This Review discusses their continued development and the challenges arising from their implementation in the clinic, such as resistance or on-target toxic effects, and the approaches that could be harnessed to overcome these obstacles.

    Source: Nature Reviews Cancer
    Categories: Hem/Onc News and Journals, Latest Headlines
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      NatureRevCancer

      NEW Review! Andreas Strasser , Gemma L. Kelly et al. discuss the manipulation of #apoptosis for cancer therapy using #BH3-mimetic drugs. ⚡https://t.co/x9Op9qwqCw @natrescancer @WEHI_research #CancerTherapy #TherapyResistance https://t.co/qTMxf6eoTn