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Mashup Score: 0
Hematopoietic stem cells are responsible for life-long blood cell production and are highly sensitive to exogenous stresses. The effects of low doses of ionizing radiations on radiosensitive tissues such as the hematopoietic tissue are still unknown despite their increasing use in medical imaging. Here, we study the consequences of low doses of ionizing radiations on differentiation and…
Source: HaematologicaCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Hematopoietic stem cells are responsible for life-long blood cell production and are highly sensitive to exogenous stresses. The effects of low doses of ionizing radiations on radiosensitive tissues such as the hematopoietic tissue are still unknown despite their increasing use in medical imaging. Here, we study the consequences of low doses of ionizing radiations on differentiation and…
Source: HaematologicaCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 3Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma - 4 year(s) ago
The BCL-2-specific inhibitor, ABT-199 (venetoclax) has exhibited remarkable clinical activity in nearly all cases of chronic lymphocytic leukemia. In contrast, responses are usually much less in diffuse large B-cell lymphoma (DLBCL), despite high level expression of BCL-2 in over 40% of cases, indicating that co-expression of related anti-apoptotic BCL-2 family proteins may limit the activity of…
Source: HaematologicaCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Analysis of the immune system of multiple myeloma patients achieving long-term disease control by multidimensional flow cytometry - 4 year(s) ago
Multiple myeloma remains largely incurable. However, a few patients experience more than 10 years of relapse-free survival and can be considered as operationally cured. Interestingly, long-term disease control in multiple myeloma is not restricted to patients with a complete response, since some patients revert to having a profile of monoclonal gammopathy of undetermined significance. We compared…
Source: HaematologicaCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
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Source: HaematologicaCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Disrupting the leukemia niche in the central nervous system attenuates leukemia chemoresistance - 4 year(s) ago
Protection from acute lymphoblastic leukemia relapse in the central nervous system (CNS) is crucial to survival and quality of life for leukemia patients. Current CNS-directed therapies cause significant toxicities and are only partially effective. Moreover, the impact of the CNS microenvironment on leukemia biology is poorly understood. In this study we showed that leukemia cells associated with…
Source: HaematologicaCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis - 4 year(s) ago
There is prevailing evidence to suggest a decisive role for platelet-derived growth factors (PDGF) and their receptors in primary myelofibrosis. While PDGF receptor β (PDGFRβ) expression is increased in bone marrow stromal cells of patients correlating with the grade of myelofibrosis, knowledge on the precise role of PDGFRβ signaling in myelofibrosis is sparse. Using the Gata-1low mouse model for…
Source: HaematologicaCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Vitamin K-dependent carboxylation of coagulation factors: insights from a cell-based functional study - 4 year(s) ago
Vitamin K-dependent carboxylation is a post-translational modification essential for the biological function of coagulation factors. Defects in carboxylation are mainly associated with bleeding disorders. With the discovery of new vitamin K-dependent proteins, the importance of carboxylation now encompasses vascular calcification, bone metabolism, and other important physiological processes. Our…
Source: HaematologicaCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 7
Alterations of the tumor suppressor gene TP53 are found in different cancers, in particular in carcinomas of adults. In pediatric acute lymphoblastic leukemia (ALL), TP53 mutations are infrequent but enriched at relapse. As in most cancers, mainly DNA-binding domain missense mutations are found, resulting in accumulation of mutant p53, poor therapy response, and inferior outcome. Different…
Source: HaematologicaCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 5Inherited thrombocytopenias: history, advances and perspectives - 4 year(s) ago
Over the last 100 years the role of platelets in hemostatic events and their production by megakaryocytes have gradually been defined. Progressively, thrombocytopenia was recognized as a cause of bleeding, first through an acquired immune disorder; then, since 1948, when Bernard-Soulier syndrome was first described, inherited thrombocytopenia became a fascinating example of Mendelian disease. The…
Source: HaematologicaCategories: Hem/Oncs, Latest HeadlinesTweet
A very interesting article on the consequences of low doses of ionizing radiations on differentiation and self-renewal capacities of human primary hematopoietic stem/progenitor cells in @Haematologica #BMTsm #HSC https://t.co/Jln1pwUvEe