• Mashup Score: 1
    Wolters Kluwer Health - 1 year(s) ago

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    • Teclistamab-cqyv is a bispecific T-cell engager that binds to the CD3 receptor on the surface of T cells and #BCMA expressed on the surface of #multiplemyeloma cells resulting in T-cell activation, proinflammatory cytokine release, and cellular lysis: https://t.co/SzuNWplZVa https://t.co/Tv6lHEDuEc

  • Mashup Score: 0
    Wolters Kluwer Health - 1 year(s) ago

    JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable JavaScript Firefox From the Tools…

    Tweet Tweets with this article
    • Teclistamab-cqyv is a bispecific T-cell engager that binds to the CD3 receptor on the surface of T cells and #BCMA expressed on the surface of #multiplemyeloma cells resulting in T-cell activation, proinflammatory cytokine release, and cellular lysis: https://t.co/SzuNWplZVa https://t.co/58DjIYBOSh

  • Mashup Score: 1

    The manufacturer is pulling the drug from the market at the request of the FDA following disappointing results from a large phase 3 confirmatory trial.

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    • #BCMA #ADC belanatamab withdrawn from the US. P3 confirmatory trial DREAMM3 (belantamab vs. PomDex) for #RRMM showed no PFS advantage (HR, 1.03; 95% CI, 0.72 – 1.47). #FDA #AcceleratedApproval mechanism works as it should!!! https://t.co/6zAp0pXgj7 https://t.co/AjKeDDnH2L

  • Mashup Score: 13

    The therapeutic landscape of multiple myeloma (MM) has been rapidly evolving with the development of newer modalities such as chimeric antigen receptor T-cell (CAR-T) therapies. Currently, there are two CAR-T cell products approved by the U.S. Food and Drug Administration for MM, idecabtagene

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    • RT @mahrefat: High antigen density of BCMA: friend or foe to CAR T cells? https://t.co/IwSbfxptMy #mmsm #BCMA @MarcelaMaus

    • High antigen density of BCMA: friend or foe to CAR T cells? https://t.co/5rSJTCJoqa