Leucine-rich repeat kinase 2 (LRRK2) is the most commonly mutated gene in familial Parkinson’s disease (PD)1 and is also linked to its idiopathic form2. LRRK2 is proposed to function in membrane trafficking3 and co-localizes with microtubules4. Despite LRRK2’s fundamental importance for understanding and treating PD, there is limited structural information on it. Here we report the 3.5Å structure…
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