Leucine-rich repeat kinase 2 (LRRK2) is the most commonly mutated gene in familial Parkinson’s disease (PD)1 and is also linked to its idiopathic form2. LRRK2 is proposed to function in membrane trafficking3 and co-localizes with microtubules4. Despite LRRK2’s fundamental importance for understanding and treating PD, there is limited structural information on it. Here we report the 3.5Å structure…
Blood Cancer Journal – What have we learned about TP53-mutated acute myeloid leukemia?
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Nature – Two-year collaboration aims to create tools to help counter the tide of flawed research.
Nature Reviews Rheumatology – In a phase III clinical trial of abatacept for idiopathic inflammatory myopathy, the primary endpoint was not met but the results…
Nature Reviews Rheumatology – The updated 2023 EULAR recommendations for treatment of systemic sclerosis bring notable changes to recommendations for skin, peripheral vascular disease, interstitial…
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Nature Reviews Gastroenterology & Hepatology – Pancreatic cancer remains one of the most challenging malignancies, with a very poor prognosis. Current research is focused on…
Nature Reviews Gastroenterology & Hepatology – Pancreatic cancer remains one of the most challenging malignancies, with a very poor prognosis. Current research is focused on…
