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Mashup Score: 0Emerging novel targeted therapies in pancreatic cancer - 9 day(s) ago
Davide Melisi, MD, PhD, University of Verona, Verona, Italy, provides an overview promising new therapeutic approaches for pancreatic cancer. Key advancements include KRAS inhibitors, targeting both allele-specific and pan-RAS mutations, which are critical due to the high mutation rate of this oncogene in pancreatic cancer. Agents modulating the immune and stromal microenvironment, such as CD40 agonists and adenosine pathway inhibitors, show potential in enhancing immune response. Synthetic lethality strategies, particularly targeting MTAP loss with PRMT5 inhibitors, and the use of PARP inhibitors in BRCA-mutated tumors combined with immune checkpoint inhibitors, also hold significant promise. This interview took place at the European Society for Medical Oncology (ESMO) 2024 Congress in Barcelona, Spain. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Source: www.vjoncology.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 2The evolution of lung cancer treatment toward personalization - 10 day(s) ago
Samreen Ahmed, University Hospitals of Leicester, UK, discusses the evolving landscape of lung cancer treatment, particularly in the curative space. The integration of neoadjuvant chemotherapy and immunotherapy before surgery marks a significant advancement, enabling systemic therapies alongside surgical interventions. Prof. Ahmed highlights the imminent emergence of perioperative treatments, encompassing neoadjuvant surgery and adjuvant therapy. She emphasizes the importance of personalized approaches in determining the necessity and extent of postoperative treatments. Additionally, she delves into the potential of circulating tumor DNA (ctDNA) as a tool for early detection and treatment decision-making, both in advanced and early-stage disease. These insights shed light on the ongoing efforts to tailor lung cancer management for individual patients. This interview took place at the BTOG 2024 congress in Belfast, UK. These works are owned by Magdalen Medical Publishing (MMP) and are p
Source: www.vjoncology.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 0New combination therapies in HER2-expressing gastric cancer - 11 day(s) ago
Kohei Shitara, MD, National Cancer Center Hospital East, Kashiwa, Japan, discusses the DESTINY-Gastric01 trial (NCT03329690) investigating IHC 1-positive (IHC1+) and IHC 2-positive (IHC2+)/ISH-negative (ISH-) patients with HER2-expressing gastric cancer. Antibody-drug conjugate (ADC) trastuzumab derutexcan (T-DXd) was administered in patients, however, to enhance activity, T-DXd will be investigated in combination with capecitabine, nivolumab and oxaliplatin, in an upcoming Phase Ib trial. This interview took place at 2024 European Society for Medical Oncology (ESMO) Gastrointestinal Cancers Annual Congress in Munich, Germany. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Source: www.vjoncology.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 0VJOncology – The video journal of oncology - 12 day(s) ago
The Video Journal of Oncology (VJOncology) is an independent, global, open-access video journal, dedicated to providing trusted and up-to-date information in order to improve the awareness and understanding of oncology
Source: www.vjoncology.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 1Treatment options in refractory metastatic colorectal cancer - 12 day(s) ago
Kathrin Heinrich, MD, Ludwig-Maximilians-Universität München, Munich, Germany, gives an overview of treatment strategies for third-line and beyond refractory metastatic colorectal cancer, focusing on various options depending on pre-treatment and molecular subtypes. These include trifluridine-tipiracil plus bevacizumab, regorafenib, and the new option of fruquintinib. For RAS wild-type patients, EGFR re-challenge is viable, and in HER2-positive cases, therapies like trastuzumab deruxtecan are considered. Molecular profiling, such as KRAS G12C analysis, will be essential to guide therapy selection. This interview took place at the European Society for Medical Oncology (ESMO) 2024 Congress in Barcelona, Spain. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Source: www.vjoncology.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 0Enhanced imaging techniques in basal cell carcinoma - 12 day(s) ago
Nicusor Iftimia, PhD, Physical Sciences, Inc., Andover, MA, discusses the integration of reflectance confocal microscopy (RCM) with optical coherence tomography (OCT) to enhance basal cell carcinoma diagnosis and therapy guidance. While dermoscopy is standard, this dual-modality approach provides submicron, cross-sectional images that help assess tumor depth, a limitation in confocal imaging alone. This technology has shown to improve diagnostic specificity and reduce unnecessary biopsies, aiding in non-surgical treatment options. This interview took place at The European Congress on Dermato-Oncology 2024 in Vienna, Austria. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Source: www.vjoncology.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 1
Andrea Apolo, MD, National Cancer Institute, Bethesda, MD, examines subset analyses in the AMBASSADOR study (NCT03244384), which assessed adjuvant pembrolizumab in urothelial cancer. PD-L1 positive patients (combined positive score ≥10) had superior disease-free survival (DFS) compared to PD-L1 negative patients, though both groups benefited from pembrolizumab. Lymph node status also impacted prognosis, with worse outcomes for higher nodal involvement (N2, N3). Recurrence patterns by metastatic sites, including lymph nodes, lungs, liver, and bones, showed slight distribution differences based on treatment, offering hypothesis-generating insights. This interview took place at the European Society for Medical Oncology (ESMO) 2024 Congress in Barcelona, Spain. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Source: www.vjoncology.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 2Advancing robotics in oncology: benefits and standardization in rectal cancer surgery - 15 day(s) ago
Jim Khan, MBBS, MSc, PhD, FCPS (Surg), FRCS (Glasg), FRCS (Gen Burg), FASCRS, Portsmouth Hospitals NHS Trust, Portsmouth, UK, discusses the growing role of robotics in oncology, particularly in the context of rectal cancer resections. He highlights the significant advancements in robotic technology over the past five years, emphasizing its benefits for precise surgery, reduced complications, and faster recovery for patients. Prof. Khan also notes the increasing interest among trainees and the need for standardization in the adoption of this technology. This interview took place at the ESSO 43 congress in Antwerp, Belgium. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Source: www.vjoncology.comCategories: General Medicine News, Oncologists1Tweet
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Mashup Score: 11
Chiara Ciccarese, MD, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, explores findings from the Phase II TACITO trial (NCT04758507) of fecal microbiota transplantation (FMT) with axitinib and pembrolizumab in metastatic renal cell carcinoma (mRCC). Results showed a significantly higher 1-year progression-free survival and improved objective response rate in the FMT group, with an acceptable safety profile. Median progression-free survival was longer with FMT, indicating potential benefits of microbiota modulation in augmenting checkpoint inhibitor-based therapies. This interview took place at the European Society for Medical Oncology (ESMO) 2024 Congress in Barcelona, Spain. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Source: www.vjoncology.comCategories: General Medicine News, Oncologists1Tweet-
Join our collaborators at @VJOncology and @ciccarese_c of Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy🇮🇹 https://t.co/5cX71vovuk As she explores findings from the Phase II TACITO trial (NCT04758507) of fecal microbiota transplantation (FMT) with axitinib… https://t.co/6dlTKsWf8d
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Mashup Score: 19
Camillo Porta, MD, A. Moro University of Bari, Bari, Italy, discusses findings from two Phase III trials, CONTACT-03 (NCT04338269) and TiNivo-2 (NCT04987203), which show that immediately sequencing immune checkpoint inhibitors after progression provides no therapeutic benefit. Currently, patients progressing on these inhibitors are treated with single anti-angiogenic agents, though the optimal approach remains uncertain. Further studies are needed to evaluate long-term immunotherapy rechallenge strategies, suggesting that while immediate rechallenge is ineffective, exploring long-term strategies could offer new therapeutic options. This interview took place at the European Society for Medical Oncology (ESMO) 2024 Congress in Barcelona, Spain. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Source: www.vjoncology.comCategories: General Medicine News, Oncologists1Tweet
November marks #PancreaticCancerAwarenessMonth & we’re thrilled to bring you the latest in treatment innovation🔦 Dive into this interview from #ESMO2024 | Emerging novel targeted therapies in #pancreaticcancer w/ @MelisiDavide🎥 Catch all the insights👉https://t.co/toag4q1VYs