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Mashup Score: 8Current Issue Table of Contents: European Urology - 9 hour(s) ago
Volume 85 Issue 6 p511-592, e151-e186 Your session will expire shortly. If you are still working, click the ‘Keep Me Logged In’ button below. If you do not respond within the next minute, you will be automatically logged
Source: www.europeanurology.comCategories: General Medicine News, UrologyTweet
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Mashup Score: 13Systemic and Tumor-directed Therapy for Oligorecurrent Metastatic Prostate Cancer (SATURN): Primary Endpoint Results from a Phase 2 Clinical Trial - 10 hour(s) ago
In men with prostate-specific membrane antigen–defined, oligorecurrent M1a–b prostate cancer, short-course androgen annihilation therapy and metastasis-directed stereotactic body radiotherapy achieved a substantial disease-free interval following testosterone recovery. This regimen was well tolerated, and 90% of patients completed therapy with androgen deprivation therapy and at least one androgen receptor pathway inhibitor.
Source: www.europeanurology.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 8Current Issue Table of Contents: European Urology - 10 hour(s) ago
Volume 85 Issue 6 p511-592, e151-e186 Your session will expire shortly. If you are still working, click the ‘Keep Me Logged In’ button below. If you do not respond within the next minute, you will be automatically logged
Source: www.europeanurology.comCategories: General Medicine News, UrologyTweet
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Mashup Score: 0Stool Microbiome Signature Associated with Response to Neoadjuvant Pembrolizumab in Patients with Muscle-invasive Bladder Cancer - 7 day(s) ago
Using preimmunotherapy stool samples collected from patients enrolled in the PURE-01 clinical trial, testing neoadjuvant pembrolizumab in patients with muscle-invasive bladder cancer, we identified some bacterial taxa that were enriched differentially in responders and nonresponders to immunotherapy. Among those, the genus Sutterella was enriched in responders, while the species Ruminococcus bromii was enriched in nonresponders. We further used an animal model of bladder cancer to provide further evidence suggesting a negative role of R. bromii in anti–PD-1 efficacy. However, further studies are needed to confirm our findings.
Source: www.europeanurology.comCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 7
Circulating-tumor DNA (ctDNA)-positive status was a negative prognostic biomarker in patients with muscle-invasive urothelial carcinoma after radical surgery and possibly a predictive biomarker for the overall survival benefit with adjuvant atezolizumab versus observation. The ctDNA-negative status possibly identified patients who experienced an unfavorable risk-benefit profile with adjuvant atezolizumab.
Source: www.europeanurology.comCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 68Management of Lymph Node–positive Penile Cancer: A Systematic Review - 2 month(s) ago
Surgery remains the standard for lymph-node (LN) metastatic penile cancer. Surveillance or delayed LN dissection (LND) risks missing a curative opportunity. Minimally invasive techniques seem to be feasible and may reduce wound related complications. (Neo)adjuvant treatment has no proven benefit in pN1 disease. More advanced disease is rarely cured by surgery alone and multimodal treatment should be considered after multidisciplinary team discussion. Further prospective and randomised trials on minimally invasive LND, multimodal/novel systemic therapies, and management of recurrent LN are needed.
Source: www.europeanurology.comCategories: General Medicine News, UrologyTweet-
Congrats to our March IMPACT Award winners @AshwinUrol and Luke McGuinness! Their article “Management of Lymph Node–positive Penile Cancer: A Systematic Review” was the most influential work featured in our March 2024 issue! Full article here: https://t.co/QVpLGFZ0k0 #UroSoMe https://t.co/d0dXqWn6Ie
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Mashup Score: 4
It is not known whether molecular urothelial cancer (UC) subtypes change during metastatic evolution. Immunohistochemistry-based and histomorphological UC subtypes remain highly stable during metastasis. The luminal tumor cell differentiation of “stroma-rich” tumors based on immunohistochemical subtyping is apparently superimposed by desmoplastic tumor stroma content in transcriptome-based subtyping.
Source: www.europeanurology.comCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 48Management of Lymph Node–positive Penile Cancer: A Systematic Review - 2 month(s) ago
Surgery remains the standard for lymph-node (LN) metastatic penile cancer. Surveillance or delayed LN dissection (LND) risks missing a curative opportunity. Minimally invasive techniques seem to be feasible and may reduce wound related complications. (Neo)adjuvant treatment has no proven benefit in pN1 disease. More advanced disease is rarely cured by surgery alone and multimodal treatment should be considered after multidisciplinary team discussion. Further prospective and randomised trials on minimally invasive LND, multimodal/novel systemic therapies, and management of recurrent LN are needed.
Source: www.europeanurology.comCategories: General Medicine News, UrologyTweet-
Congrats to our March IMPACT Award winners @AshwinUrol and Luke McGuinness! Their article “Management of Lymph Node–positive Penile Cancer: A Systematic Review” was the most influential work featured in our March 2024 issue! Full article here: https://t.co/QVpLGFZ0k0 #UroSoMe https://t.co/d0dXqWn6Ie
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Mashup Score: 10Systemic and Tumor-directed Therapy for Oligometastatic Prostate Cancer: The SOLAR Phase 2 Trial in De Novo Oligometastatic Prostate Cancer - 2 month(s) ago
We conducted a trial in which effective multimodal therapies without long-term castration were combined with the aim of achieving durable remission in patients with de novo oligometastatic prostate cancer. Here we report primary analysis results from SOLAR, a single-arm prospective phase 2 trial of primary tumor–directed therapy, metastasis-directed therapy (MDT) [1], and intensified systemic therapy of limited duration conducted within the Veterans Affairs health care system.
Source: www.europeanurology.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 11Germline Exome Sequencing for Men with Testicular Germ Cell Tumor Reveals Coding Defects in Chromosomal Segregation and Protein-targeting Genes - 2 month(s) ago
This exome sequencing study of 293 men with familial or bilateral testicular germ cell tumor (TGCT) and 3157 cancer-free controls is the largest of its kind. Using a gene-agnostic approach, we identified germline coding changes associated with TGCT.
Source: www.europeanurology.comCategories: General Medicine News, Oncologists2Tweet
June issue is out now! Read all of the articles here: https://t.co/UeoxPNdooU #UroSoMe #Medtwitter https://t.co/4fKvT8KNXb