Musical murmurs are distinct auscultatory findings that sound like a pure musical tone. These murmurs are sometimes called “dove-coo murmur” or “seagull’s cry murmur.”1-3 In 1880, musical systolic murmur was first reported by William Osler.4 Since then, musical systolic murmurs have been mostly reported in cases of mitral valve prolapse.3,5,6 Musical diastolic murmurs are relatively uncommon and are usually associated with aortic regurgitation (AR).1,2,7 Musical diastolic murmurs had been well-known in AR due to syphilitic aortitis.

Kawasaki disease (KD) is a systemic vasculitis that is predominantly a clinical diagnosis as defined by the American Heart Association. Kawasaki disease has become the most common cause of acquired heart disease in children due to a predilection for targeting the coronary arteries, with approximately 25% of untreated cases developing coronary artery aneurysms (CAAs). Although it is a self-limited diagnosis, early diagnosis and treatment is the key to reduce inflammation and potential for damage to the arterial wall with risk for developing coronary artery ectasia and CAAs.

Arterial tortuosity syndrome (ATS, OMIM no. 208050) is an extremely rare autosomal recessive connective tissue disorder caused by biallelic pathogenic variants that cause loss of function in the SLC2A10 gene and is characterized by widespread elongation and tortuosity of medium- and large-sized arteries that place patients at risk for stenoses and aneurysm formation.1 Prenatal detection of ATS remains extremely rare. To date, just over 100 patients have been reported with ATS, with only a few prenatally detected cases described in the literature.