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Mashup Score: 7
Since the successful pivotal studies of pirfenidone (1) and nintedanib (2) for idiopathic pulmonary fibrosis (IPF), several drugs have shown promise in early-phase clinical trials (3, 4) only to fail on efficacy grounds in registrational studies (5). With antifibrotic therapy representing standard of care, successful trials rely on demonstrating further attenuation in FVC decline. Enrolling patients who remain stable over the course of a clinical trial represents a risk, as progression is necessary to be
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 6Ambient Ultrafine Particulate Matter and Clinical Outcomes in Fibrotic Interstitial Lung Disease - 2 day(s) ago
Rationale: Particulate matter with an aerodynamic diameter ⩽2.5 μm is associated with adverse outcomes in fibrotic interstitial lung disease (fILD), but the impact of ultrafine particulates (UFPs; …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 3
Recent years have seen a growing interest in the early detection of interstitial lung disease (I LD) and its potential implications for clinical care. One of the most promising tools for early ILD detection is computed tomography–based assessment, which has been shown to effectively identify ILD together with interstitial lung abnormalities (ILAs), which refer to incidentally detected features of ILD such as reticulation and honeycombing (1). Because ILAs can progress to overt ILD and are associated with
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Mashup Score: 1Everything Everywhere All at Once? Identifying Exposures and Outcomes that Matter to Families within and beyond the Intensive Care Unit - 3 day(s) ago
As care for critically ill patient s has advanced, so too has our recognition of the multidimensional and persistent morbidities that affect patients and their families following an intensive care unit (ICU) stay (1). Survivors of critical illness experience impairments across multiple domains of health—physical, cognitive, emotional, social, and financial—that can persist months to years after hospital discharge (2 – 4). Family members frequently serve as surrogate decision-makers for their loved ones
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 2When a DEAD-Box Protein Is the Key: A Novel Role for DDX5 in Lung Pericyte Dysfunction - 3 day(s) ago
Intrauterine growth restriction (IUGR) is characterized by fetal weight below the 10th percentile per gestational age, increased risk for various conditions, and premature death (1). Infants with IUGR are at an increased risk of the development of pulmonary hypertension (PH), a devastating condition characterized by increased pulmonary artery pressures and remodeling of the pulmonary vasculature (1). Among the potential causes of IUGR-associated PH is the arrested development of the pulmonary vascular
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Mashup Score: 2Validation of Constant Work Rate Cycling Endurance Time for Use in Chronic Obstructive Pulmonary Disease Clinical Trials - 3 day(s) ago
Rationale: A COPD Foundation working group sought to identify measures of exercise endurance, a meaningful aspect of physical functioning in everyday life among patients with chronic obstructive pu…
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 6Ambient Ultrafine Particulate Matter and Clinical Outcomes in Fibrotic Interstitial Lung Disease - 3 day(s) ago
Rationale: Particulate matter with an aerodynamic diameter ⩽2.5 μm is associated with adverse outcomes in fibrotic interstitial lung disease (fILD), but the impact of ultrafine particulates (UFPs; …
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 2
The overarching goal of medical education is to train clinicians who achieve and maintain competence in patient care. Although the field of medical education research has acknowledged the importanc…
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Mashup Score: 2Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis - 3 day(s) ago
Chronic obstructive pulmonary disease (COPD) remains a major public health challenge that contributes greatly to mortality and morbidity worldwide. Although it has long been recognized that the epi…
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Mashup Score: 11Climate Change - 3 day(s) ago
The American Journal of Respiratory Cell and Molecular Biology (AJRCMB) is issuing a call for papers: “Climate Change: Cellular and Molecular Mechanisms Impacting Lung Pathobiology.” This call aims to showcase work that investigate the mechanisms by which environmental climate change-related factors impact lung health and disease either directly, or through interaction with other elements (e.g., ozone, PM2.5, allergens, pathogens). The Journal welcomes Original Research, Perspectives, Major Technical
Source: www.atsjournals.orgCategories: General Medicine News, PulmonologyTweet
e-Lung Computed Tomography Biomarker Stratifies Patients at Risk of Idiopathic Pulmonary Fibrosis Progression in a 52-Week Clinical Trial An AI-powered algorithm stratified patients at risk of progression from a baseline CT scan @DrPeter_George https://t.co/yt4uLx0rcY https://t.co/3GfaBJSBBI