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Mashup Score: 12The Crucial Role of Genetic Testing in Amyloidosis - 12 day(s) ago
What is Hereditary ATTR (hATTR)? Hereditary transthyretin-mediated amyloidosis (hATTR) is an inherited genetic condition affecting a protein called transthyretin (TTR). 1 A variant in the TTR gene causes the protein to become abnormally shaped and misfolded. This misfolded TTR forms amyloid fibrils which can build up and deposit in the nerves, digestive system, heart and other tissues and organs, causing a variety of symptoms such as numbness, pain or tingling in the hands and feet, shortness of breath,
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Mashup Score: 6
AstraZeneca and Daiichi Sankyo’s ENHERTU ® (fam-trastuzumab deruxtecan-nxki) has been approved in the US for the treatment of adult patients with unresectable or metastatic HER2-positive (IHC 3+) solid tumors who have received prior systemic treatment and have no satisfactory alternative treatment options. This indication is approved under accelerated approval based on objective response rate (ORR) and duration of response (DoR). Continued approval for this indication may be contingent upon verification
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Mashup Score: 9
Positive high-level results of the ADRIATIC Phase III trial showed AstraZeneca’s IMFINZI® (durvalumab) demonstrated a statistically significant and clinically meaningful improvement in the dual primary endpoints of overall survival (OS) and progression-free survival (PFS) in patients with limited-stage small cell lung cancer (LS-SCLC) who had not progressed following concurrent chemoradiotherapy (cCRT) compared to placebo after cCRT. Small cell lung cancer (SCLC) is a highly aggressive form of lung
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Mashup Score: 6
AstraZeneca and Daiichi Sankyo’s Biologics License Application (BLA) for datopotamab deruxtecan (Dato-DXd) has been accepted in the US for the treatment of adult patients with unresectable or metastatic hormone receptor (HR)-positive, HER2-negative (IHC 0, IHC 1+ or IHC 2+/ISH-) breast cancer who have received prior systemic therapy for unresectable or metastatic disease. The Prescription Drug User Fee Act date, the US Food and Drug Administration (FDA) action date for its regulatory decision, is during
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Mashup Score: 0
Whether you are scheduling a routine check-up or looking to better understand your current condition, the average person in the United States waits approximately 26 days before they’re able to see their primary care provider (PCP) in person – and the process can be even more complicated for the 30% of patients who don’t have a PCP. 1 A lack of structure or tools to support health literacy, need for savings program support, and geographic challenges to accessing appropriate care can create additional
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Mashup Score: 3
Latest analysis of the results from the DUO-E Phase III trial showed IMFINZI ® (durvalumab) plus platinum-based chemotherapy followed by IMFINZI plus LYNPARZA ® (olaparib) (LYNPARZA and IMFINZI arm) demonstrated an improvement in multiple key secondary efficacy endpoints, particularly in patients with mismatch repair proficient (pMMR) advanced or recurrent endometrial cancer compared to chemotherapy alone. These results will be presented today in a late-breaking session at the 2024 Society of Gynecologic
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Mashup Score: 5Understanding ATTR: The Challenges of Amyloidosis - 1 month(s) ago
Transthyretin amyloidosis (ATTR) is a complex medical condition that happens when a protein called transthyretin (TTR) does something different than what it’s supposed to do in the body. Normally, TTR is a four-piece protein produced mostly in the liver that helps carry important substances, like thyroxine (thyroid hormones) and vitamin A, throughout the body. When someone has ATTR, the pieces of TTR fall apart, misfold, and change shape. These pieces bind together to form larger structures called
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Mashup Score: 3National Kidney Month – Speaking with Your Doctor about CKD - 1 month(s) ago
March is National Kidney Month—a time to raise awareness about the importance of kidney health. Chronic Kidney Disease (CKD) affects an estimated 37 million Americans, and it is often referred to as a “silent disease” because there are usually no symptoms during its early stages. In fact, as many as 90% of Americans who have chronic kidney disease (CKD) don’t know they have it until it is very advanced. The kidneys play an important role in helping our bodies function properly. When the kidneys are
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#DidYouKnow that early detection is key to slowing the progression of chronic kidney disease (CKD)? This #NationalKidneyMonth and #WorldKidneyDay, speak to your doctor about #CKD risk factors and develop a management plan that’s right for you. Learn more: https://t.co/Yxo3Z5UeJA https://t.co/9Xoh68AVyj
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Mashup Score: 0National Kidney Month – Speaking with Your Doctor about CKD - 2 month(s) ago
March is National Kidney Month—a time to raise awareness about the importance of kidney health. Chronic Kidney Disease (CKD) affects an estimated 37 million Americans, and it is often referred to as a “silent disease” because there are usually no symptoms during its early stages. In fact, as many as 90% of Americans who have chronic kidney disease (CKD) don’t know they have it until it is very advanced. The kidneys play an important role in helping our bodies function properly. When the kidneys are
Source: www.astrazeneca-us.comCategories: General Medicine News, PayerTweet-
It’s #NationalKidneyMonth. Did you know that earlier detection of #ChronicKidneyDisease (CKD) can improve patient outcomes, limiting the impact on health systems, caregivers, economies and the environment? Learn more about #CKD management and our promise: https://t.co/hgHUNfOgHm https://t.co/VLjPy9yaj1
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Mashup Score: 0That's Understandable - 2 month(s) ago
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Genetic testing plays an important role in diagnosing hereditary transthyretin- mediated amyloidosis (hATTR). Learn more about the process and whether it may be right for you and your loved ones: https://t.co/GXv9pF45F1 https://t.co/a3IGpzYiSE