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Mashup Score: 0Integrated Transcriptomic and Proteomic Analysis Identifies Plasma Biomarkers of Hepatocellular Failure in Alcohol-Associated Hepatitis - 1 year(s) ago
Alcohol-associated hepatitis (AH) is a form of liver failure with high short-term mortality. Recent studies have shown that defective function of hepatocyte nuclear factor 4 alpha (HNF4a) and systemic inflammation are major disease drivers of AH. Plasma biomarkers of hepatocyte function could be useful for diagnostic and prognostic purposes. Herein, an integrative analysis of hepatic RNA…
Categories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 3
Genetic variants of SARS-CoV-2 continue to dramatically alter the landscape of the COVID-19 pandemic. The recently described variant of concern designated Omicron (B.1.1.529) has rapidly spread worldwide and is now responsible for the majority of COVID-19 cases in many countries. Because Omicron was recognized very recently, many knowledge gaps exist about its epidemiology, clinical severity, and…
Categories: General Medicine News, Latest HeadlinesTweet-
Signals of significantly increased vaccine breakthrough, decreased hospitalization rates, and less severe disease in patients with COVID-19 caused by the Omicron variant of SARS-CoV-2 in Houston, Texas https://t.co/D3xajgYXES
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Mashup Score: 0
Although human placental tissues may be infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the rate of fetal transmission is low, suggesting either viral neutralization or a barrier at the maternal-fetal interface. Angiotensin-converting enzyme (ACE)-2, the main receptor for SARS-CoV-2, is expressed as cell surface and soluble forms regulated by a metalloprotease cleavage…
Categories: Healthcare Professionals, Latest HeadlinesTweet-
Acute SARS-CoV-2 Infection in Pregnancy Is Associated with Placental ACE2 Shedding https://t.co/G5IwEECtjz To protect the fetus in the 3rd trimester, the placenta sheds ACE2 so that SARS-CoV-2 cannot enter. Elevated soluble ACE2 is seen in 3rd trimester COVID infected mothers. https://t.co/LdOnvfQOU3
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Mashup Score: 15Coronavirus Disease 2019 (COVID-19) Coronary Vascular Thrombosis - 2 year(s) ago
Severe coronavirus disease 2019 (COVID-19) increases the risk of myocardial injury that contributes to mortality. This study used multiparameter immunofluorescence to extensively examine heart autopsy tissue of 7 patients who died of COVID-19 compared to 12 control specimens, with or without cardiovascular disease. Consistent with prior reports, no evidence of viral infection or lymphocytic…
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Coronavirus Disease 2019 (COVID-19) Coronary Vascular Thrombosis https://t.co/To6zPoodbg
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Mashup Score: 0Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes - 3 year(s) ago
Approximately 10% to 15% of human cancers lack detectable telomerase activity, and a subset of these maintain telomere lengths by the telomerase-independent telomere maintenance mechanism termed alternative lengthening of telomeres (ALT). The ALT phenotype, relatively common in subtypes of sarcomas and astrocytomas, has rarely been reported in epithelial malignancies. However, the prevalence of…
Categories: Hem/Oncs, Latest HeadlinesTweet-
This study is in the context of ATRX mutant low grade gliomas with ALT. Overall, ~4% of ALL cancers, including a fair percentage of pancreatic #neuroendocrine tumors and many pediatric neoplasms, have ALT as a phenotype. Can’t wait to see how this evolves. https://t.co/3lfF5Ut1Br
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Mashup Score: 2
One of the major obstacles to reach diagnostic consensus is observer variability. With the recent success of artificial intelligence, particularly the deep networks, the question emerges whether we can now solve diagnostic imaging’s fundamental challenge. This paper briefly reviews the problem and how eventually both supervised and unsupervised AI technologies could help overcome it.
Categories: Latest Headlines, PathologyTweet-
RT @ASIPath: @AJPathology News: Searching Images for Consensus: Can AI Remove Observer Variability in Pathology? https://t.co/Jxq4DfKeBJ A…
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Mashup Score: 0Acute Respiratory Distress in Aged, SARS-CoV-2 Infected African Green Monkeys but not Rhesus Macaques - 4 year(s) ago
SARS-CoV-2 induces a wide range of disease severity ranging from asymptomatic infection, to a life-threating illness, particularly in the elderly and persons with comorbid conditions. Among those persons with serious COVID-19 disease, acute respiratory distress syndrome (ARDS) is a common and often fatal presentation. Animal models of SARS-CoV-2 infection that manifest severe disease are needed…
Categories: Healthcare Professionals, Latest HeadlinesTweet-
And yes. There is⏩actual evidence⏪ that small particle *aerosols* (SPA; not droplets-although I can't find the specific SPA size range in this paper) infect & result in inflammation and can generate ARDS (highlighted below were SPA infected) in primates https://t.co/eBsV3hTRhY https://t.co/RxojVH5Dfm
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Mashup Score: 5Acute Respiratory Distress in Aged, SARS-CoV-2 Infected African Green Monkeys but not Rhesus Macaques - 4 year(s) ago
SARS-CoV-2 induces a wide range of disease severity ranging from asymptomatic infection, to a life-threating illness, particularly in the elderly and persons with comorbid conditions. Among those persons with serious COVID-19 disease, acute respiratory distress syndrome (ARDS) is a common and often fatal presentation. Animal models of SARS-CoV-2 infection that manifest severe disease are needed…
Categories: Healthcare Professionals, Latest HeadlinesTweet-
"Despite the 3-log difference in exposure dose, no significant difference was observed in the viral RNA loads or kinetics based on the route of exposure" https://t.co/eBsV3hTRhY
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Mashup Score: 1Treatment of COVID-19 Patients with Convalescent Plasma Reveals a Signal of Significantly Decreased Mortality - 4 year(s) ago
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has spread globally, and proven treatments are limited. Transfusion of convalescent plasma collected from donors who have recovered from COVID-19 is among many approaches being studied as potentially efficacious therapy. We are conducting a prospective, propensity score-matched study assessing the…
Categories: Healthcare Professionals, Latest HeadlinesTweet-
Best of – Early results are encouraging: Plasma donated by people who have recovered from COVID-19 can save lives. https://t.co/fnU1kYOPvF
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Mashup Score: 5Treatment of COVID-19 Patients with Convalescent Plasma Reveals a Signal of Significantly Decreased Mortality - 4 year(s) ago
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has spread globally, and proven treatments are limited. Transfusion of convalescent plasma collected from donors who have recovered from COVID-19 is among many approaches being studied as potentially efficacious therapy. We are conducting a prospective, propensity score-matched study assessing the…
Categories: Hem/Oncs, Latest HeadlinesTweet-
Treatment of COVID-19 Patients with Convalescent Plasma Reveals a Signal of Significantly Decreased Mortality - The American Journal of Pathology https://t.co/n5DqjIaLD9
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Integrated Transcriptomic and Proteomic Analysis Identifies Plasma Biomarkers of Hepatocellular Failure in Alcohol-Associated Hepatitis https://t.co/EsKDDlHZYK