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Mashup Score: 1Evolution of congenital anomalies of urinary tract in children with and without solitary kidney - Pediatric Research - 2 year(s) ago
We hypothesized that children with congenital solitary functioning kidney (CSFK) present forms of congenital urinary tract anomalies (CUTA) with higher chance of spontaneous resolution compared with patients with two kidneys. We retrospectively selected 75 consecutive children with CUTA of the CSFK and 75 matched patients with unilateral CUTA but without CSFK (controls) with prenatal suspicion of…
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Mashup Score: 0Knowledge gaps in late-onset neonatal sepsis in preterm neonates: a roadmap for future research - Pediatric Research - 2 year(s) ago
Late-onset neonatal sepsis (LONS) remains an important threat to the health of preterm neonates in the neonatal intensive care unit. Strategies to optimize care for preterm neonates with LONS are likely to improve survival and long-term neurocognitive outcomes. However, many important questions on how to improve the prevention, early detection, and therapy for LONS in preterm neonates remain…
Source: Pediatric ResearchCategories: Latest Headlines, PediatricsTweet
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Mashup Score: 0Higher CPAP levels improve functional residual capacity at birth in preterm rabbits - Pediatric Research - 2 year(s) ago
Preterm infants are commonly supported with 4–8 cm H2O continuous positive airway pressures (CPAP), although higher CPAP levels may improve functional residual capacity (FRC). Preterm rabbits delivered at 29/32 days (~26–28 weeks human) gestation received 0, 5, 8, 12, 15 cm H2O of CPAP or variable CPAP of 15 to 5 or 15 to 8 cm H2O (decreasing ~2 cm H2O/min) for up to 10 min after birth. FRC was…
Source: Pediatric ResearchCategories: Latest Headlines, PediatricsTweet
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Mashup Score: 0The impact of intrauterine and extrauterine weight gain in premature infants on later body composition - Pediatric Research - 2 year(s) ago
The impact of intrauterine and extrauterine growth on later insulin resistance and fat mass (FM) in very low birth weight (VLBW) infants is not well established. The aim of our study was to evaluate the effects of intrauterine and early/late extrauterine growth on later insulin resistance and body composition in VLBW infants from 6 months’ corrected age (CA) to 36 months. Prospective measurements…
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Mashup Score: 0Stimulating and maintaining spontaneous breathing during transition of preterm infants - Pediatric Research - 2 year(s) ago
Most preterm infants breathe at birth, but need additional respiratory support due to immaturity of the lung and respiratory control mechanisms. To avoid lung injury, the focus of respiratory support has shifted from invasive towards non-invasive ventilation. However, applying effective non-invasive ventilation is difficult due to mask leak and airway obstruction. The larynx has been overlooked…
Source: Pediatric ResearchCategories: Latest Headlines, PediatricsTweet
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Mashup Score: 0The bioavailability and maturing clearance of doxapram in preterm infants - Pediatric Research - 2 year(s) ago
Doxapram is used for the treatment of apnea of prematurity in dosing regimens only based on bodyweight, as pharmacokinetic data are limited. This study describes the pharmacokinetics of doxapram and keto-doxapram in preterm infants. Data (302 samples) from 75 neonates were included with a median (range) gestational age (GA) 25.9 (23.9–29.4) weeks, bodyweight 0.95 (0.48–1.61) kg, and postnatal age…
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Mashup Score: 7
The quality of family-centered care and parental participation in care in neonatal units differ widely across the world. Appropriate education might be an effective way to support medical staff in neonatal units to collaborate with parents and implement family-centered care. The aim of this study was to evaluate the effects of the educational intervention on the quality of family-centered care in…
Source: Pediatric ResearchCategories: Latest Headlines, PediatricsTweet
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Mashup Score: 4Sex-specific relationships of the infant microbiome and early-childhood behavioral outcomes - Pediatric Research - 3 year(s) ago
A link between the gut microbiome and behavior is hypothesized, but most previous studies are cross-sectional or in animal models. The modifying role of host sex is poorly characterized. We aimed to identify sex-specific prospective associations between the early-life gut microbiome and preschool-age neurobehavior. In a prospective cohort, gut microbiome diversity and taxa were estimated with 16S…
Source: Pediatric ResearchCategories: Latest Headlines, PediatricsTweet
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Mashup Score: 11Umbilical cord blood culture in neonatal early-onset sepsis: a systematic review and meta-analysis - Pediatric Research - 3 year(s) ago
Peripheral blood culture (PBC) is considered the gold standard for diagnosis of neonatal early-onset sepsis (EOS), but its diagnostic value can be questioned. We aimed to systematically asses the diagnostic test accuracy (DTA) of umbilical cord blood culture (UCBC) for EOS. A systematic literature search was performed in PubMed, Embase, Web of Science, and the Cochrane Library. Studies performing…
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Mashup Score: 1Neonatal encephalopathy plasma metabolites are associated with neurodevelopmental outcomes - Pediatric Research - 3 year(s) ago
To investigate mechanisms of injury and recovery in neonatal encephalopathy (NE), we performed targeted metabolomic analysis of plasma using liquid chromatography with tandem mass spectrometry (LC/MS/MS) from healthy term neonates or neonates with NE. Plasma samples from the NE (n = 45, day of life 0–1) or healthy neonatal (n = 30, ≥36 weeks gestation) cohorts had LC/MS/MS metabolomic profiling…
Source: Pediatric ResearchCategories: Latest Headlines, PediatricsTweet
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