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Mashup Score: 1Integrative multiomics-histopathology analysis for breast cancer classification - npj Breast Cancer - 2 year(s) ago
Histopathologic evaluation of biopsy slides is a critical step in diagnosing and subtyping breast cancers. However, the connections between histology and multi-omics status have never been systematically explored or interpreted. We developed weakly supervised deep learning models over hematoxylin-and-eosin-stained slides to examine the relations between visual morphological signal, clinical…
Source: npj Breast CancerCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 0Matched cohort study of germline BRCA mutation carriers with triple negative breast cancer in brightness - npj Breast Cancer - 3 year(s) ago
In the BrighTNess trial, carboplatin added to neoadjuvant chemotherapy (NAC) was associated with increased pathologic complete response (pCR) rates in patients with stage II/III triple-negative breast cancer (TNBC). In this matched cohort study, cases with a germline BRCA1/2 mutation (gBRCA; n = 75) were matched 1:2 with non-gBRCA controls (n = 150) by treatment arm, lymph node status, and age to…
Source: npj Breast CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
As neoadj chemo escalates for #tnbc patients... ➡️Do gBRCA carriers benefit more...or need less? "Matched cohort study of germline BRCA mutation carriers w TNBC in BrighTNess" @Nature_NPJ #BreastCancer @Otto_DFCI @DanaFarber @ALLIANCE_org @OSUCCC_James https://t.co/WYc5mvwoWe
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Mashup Score: 1
Obese women with hormone receptor-positive breast cancer exhibit poor response to therapy and inferior outcomes. However, the underlying molecular mechanisms by which obesity/hyperleptinemia may reduce the efficacy of hormonal therapy remain elusive. Obese mice with hyperleptinemia exhibit increased tumor progression and respond poorly to tamoxifen compared to non-obese mice. Exogenous leptin…
Source: npj Breast CancerCategories: Hematologists1, Latest HeadlinesTweet-
Leptin reduces the efficacy of tamoxifen https://t.co/6i6buOj1by
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Mashup Score: 0TERT promoter hotspot mutations and gene amplification in metaplastic breast cancer - npj Breast Cancer - 3 year(s) ago
Metaplastic breast cancers (MBCs) are characterized by complex genomes, which seem to vary according to their histologic subtype. TERT promoter hotspot mutations and gene amplification are rare in common forms of breast cancer, but present in a subset of phyllodes tumors. Here, we sought to determine the frequency of genetic alterations affecting TERT in a cohort of 60 MBCs with distinct…
Source: npj Breast CancerCategories: Latest Headlines, Oncologists1Tweet-
I have seen a few rapidly progressive metaplastic TNBCs with TERT promoter mutations lately. Any smart people out there know how to target? Let’s talk. #bcsm https://t.co/r2XLQbs27D
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Mashup Score: 0Allostatic load: a framework to understand breast cancer outcomes in Black women - npj Breast Cancer - 3 year(s) ago
npj Breast Cancer –
Allostatic load: a framework to understand breast cancer outcomes in Black… Source: npj Breast CancerCategories: Latest Headlines, Oncologists1Tweet-
Excited to share our paper in @Nature_NPJ Breast Cancer on allostatic load as a framework to understand breast cancer disparities in Black women. #bcsm @OSUSurgery @OSUCCC_James @ruthcarlosmd https://t.co/VKScFHDu8l
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Mashup Score: 1The temporal mutational and immune tumour microenvironment remodelling of HER2-negative primary breast cancers - 3 year(s) ago
The biology of breast cancer response to neoadjuvant therapy is underrepresented in the literature and provides a window-of-opportunity to explore the genomic and microenvironment modulation of tumours exposed to therapy. Here, we characterised the mutational, gene expression, pathway enrichment and tumour-infiltrating lymphocytes (TILs) dynamics across different timepoints of 35 HER2-negative…
Source: npj Breast CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
The biology of breast cancer response to neoadjuvant therapy is underdescribed. Mutational heterogeneity, subclonal architecture, the improvement of immune microenvironment along with remodelling of hypoxia & EMTinfluence the response to neoadjuvant tt https://t.co/U2aQUuQaDG https://t.co/lfhprxKqzG
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Mashup Score: 0Whole-exome sequencing identifies somatic mutations and intratumor heterogeneity in inflammatory breast cancer - 3 year(s) ago
Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer. Although it is a rare subtype, IBC is responsible for roughly 10% of breast cancer deaths. In order to obtain a better understanding of the genomic landscape and intratumor heterogeneity (ITH) in IBC, we conducted whole-exome sequencing of 16 tissue samples (12 tumor and four normal samples) from six…
Source: npj Breast CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
Two papers on whole exosome sequencing of inflammatory breast cancer. We still do not know how to translate this into the clinic or link it to a biological meaning. :( https://t.co/1JtdHAEff2 and https://t.co/6n1YkS8f4Y #TalkIBC #bcsm
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Mashup Score: 0Breast cancer gene expression datasets do not reflect the disease at the population level - 3 year(s) ago
Publicly available tumor gene expression datasets are widely reanalyzed, but it is unclear how representative they are of clinical populations. Estimations of molecular subtype classification and prognostic gene signatures were calculated for 16,130 patients from 70 breast cancer datasets. Collated patient demographics and clinical characteristics were sparse for many studies. Considerable…
Source: npj Breast CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
So incredibly sad - I followed Andy’s work on breast cancer bioinformatics over the years, incl paper last year in @Nature_NPJ Breast Cancer on public datasets failure to represent population data: https://t.co/JBR4k9eC9u https://t.co/1mPihxfqto
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Mashup Score: 2The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data - 3 year(s) ago
While many studies have evaluated the relationship between BMI and breast cancer outcomes, it is unclear whether this relationship is consistent between early breast cancer (BC) and advanced BC. The study included 5099 patients with HER2 positive early BC (EBC) and 3496 with HER2 positive advanced BC (ABC). In the EBC cohort, higher BMI was associated with worse overall survival (OS) (HR [95%…
Source: npj Breast CancerCategories: Healthcare Professionals, Latest HeadlinesTweet-
RT @DanielJDrucker: Evidence of absence for the #obesity paradox in subtypes of #breastcancer @Nature_NPJ https://t.co/DZ6uYWNDHd
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Mashup Score: 0DNA methylation markers predict recurrence-free interval in triple-negative breast cancer - 4 year(s) ago
We lack tools to risk-stratify triple-negative breast cancer (TNBC). Our goal was to develop molecular tools to predict disease recurrence. Methylation array analysis was performed on 110 samples treated by locoregional therapy obtained from institutional cohorts. Discovered marker sets were then tested by Kaplan−Meier analyses in a prospectively collected TNBC cohort of 49 samples from the…
Source: npj Breast CancerCategories: Future of MedicineTweet-
"DNA methylation markers predict recurrence-free interval in triple-negative breast cancer" via @HopkinsMedicine researchers. Best, -NK & @NEBiolabs #epigenetics #CancerResearch #biomarkers https://t.co/4TLj00O7hS
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3. Ektefaie et al. use deep learning to examine the relations between H&E images and clinical subtyping, gene expression, and mutation status in breast cancer. @YEktefaie @kunhsingyu https://t.co/MlTj1qgK0A