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Mashup Score: 18Nuclear receptors in podocyte biology and glomerular disease - Nature Reviews Nephrology - 2 year(s) ago
Nuclear receptors have important roles in normal physiological functions and in the pathophysiology of various diseases. Here, the authors focus on the roles of nuclear receptors in podocyte biology and non-diabetic glomerular disease as well as their potential as therapeutic targets.
Source: Nature Reviews NephrologyCategories: Latest Headlines, NephrologyTweet
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Mashup Score: 11Immunopathophysiology of trauma-related acute kidney injury - Nature Reviews Nephrology - 2 year(s) ago
Acute kidney injury is a common complication of trauma. Here, the authors examine how, in addition to direct trauma to the kidneys, the pathophysiological responses to traumatic injuries in distant organs, including immune responses, can result in kidney dysfunction.
Source: Nature Reviews NephrologyCategories: Latest Headlines, NephrologyTweet
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Mashup Score: 12Expanding the therapy options for diabetic kidney disease - Nature Reviews Nephrology - 2 year(s) ago
New DAPA-CKD trial analyses have confirmed the outstanding renoprotective benefits of sodium–glucose co-transporter 2 inhibitors, independently of the presence of diabetes or the stage of kidney disease. Moreover, the non-steroidal mineralocorticoid receptor antagonist finerenone provides renal and cardiovascular protection in diabetic kidney disease when combined with…
Source: Nature Reviews NephrologyCategories: Latest Headlines, NephrologyTweet
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Mashup Score: 5Advances in fluorescence microscopy techniques to study kidney function - Nature Reviews Nephrology - 2 year(s) ago
This Review provides an overview of fluorescence-based microscopy techniques that have been used to study molecular processes within the kidney. The authors describe how the development of cutting-edge technologies has enabled high spatiotemporal resolution of molecular interactions and processes, and how these approaches have aided our understanding of kidney dynamics.
Source: Nature Reviews NephrologyCategories: Latest Headlines, NephrologyTweet
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Mashup Score: 8
In vivo non-invasive molecular imaging techniques have potential to improve clinical research and practices in nephrology. Here, the authors discuss the benefits and challenges of preclinical and clinical applications of molecular imaging to acute kidney injury and chronic kidney disease, transplantation and kidney cancer.
Source: Nature Reviews NephrologyCategories: Latest Headlines, NephrologyTweet
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Mashup Score: 2Challenges of access to kidney care for children in low-resource settings - Nature Reviews Nephrology - 2 year(s) ago
Many children die from preventable and/or treatable kidney disease in low-resource settings. Here, the authors examine strategies to improve the care of these children, including the need to invest in disease prevention and early detection, promote disease awareness and education, and adapt treatments to expand provision.
Source: Nature Reviews NephrologyCategories: Latest Headlines, NephrologyTweet
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Mashup Score: 23Liquid biopsies: donor-derived cell-free DNA for the detection of kidney allograft injury - Nature Reviews Nephrology - 2 year(s) ago
In transplantation, liquid biopsies that can detect donor-derived cell-free DNA (dd-cfDNA) might improve monitoring of organ rejection without invasive biopsies, and might enable effective management of anti-rejection drug therapies. Here, the authors discuss dd-cfDNA quantification methods, the clinical validity of these approaches, their limitations and economic implications.
Source: Nature Reviews NephrologyCategories: Latest Headlines, NephrologyTweet
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Mashup Score: 29
Available data suggest that the prevalence and incidence of kidney stones is increasing; however, much of this variation might result from differences in approaches used to identify stone formers. This Review describes the need for a classification system to facilitate use of consistent terminology and enable meaningful comparisons of the burden of kidney stone disease across different…
Source: Nature Reviews NephrologyCategories: Latest Headlines, NephrologyTweet
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Mashup Score: 37Kidney and epigenetic mechanisms of salt-sensitive hypertension - Nature Reviews Nephrology - 2 year(s) ago
In this Review, the authors discuss the renal mechanism of salt-sensitive hypertension induced by malnutrition during pregnancy, obesity in adult life and ageing. They also describe the epigenetic mechanisms that potentially contribute to the development of salt-sensitive hypertension in these settings.
Source: Nature Reviews NephrologyCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 17Kidney and epigenetic mechanisms of salt-sensitive hypertension - Nature Reviews Nephrology - 2 year(s) ago
In this Review, the authors discuss the renal mechanism of salt-sensitive hypertension induced by malnutrition during pregnancy, obesity in adult life and ageing. They also describe the epigenetic mechanisms that potentially contribute to the development of salt-sensitive hypertension in these settings.
Source: Nature Reviews NephrologyCategories: Cardiologists, Latest HeadlinesTweet
Mineralocorticoid receptor signalling in podocytes. https://t.co/i7qkZSylSE https://t.co/Jhxwr1NWKh