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Mashup Score: 1Genomic characteristics of invasive mucinous adenocarcinoma of the lung with multiple pulmonary sites of involvement - Modern Pathology - 3 year(s) ago
Invasive mucinous adenocarcinoma (IMA) of the lung frequently presents with diffuse pneumonic-type features or multifocal lesions, which are regarded as a pattern of intrapulmonary metastases. However, the genomics of multifocal IMAs have not been well studied. We performed whole exome sequencing on samples taken from 2 to 5 regions in seven patients with synchronous multifocal IMAs of the lung…
Source: Modern PathologyCategories: Latest Headlines, PathologyTweet
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Mashup Score: 0Clinicopathologic and prognostic features of TdT-negative pediatric B-lymphoblastic leukemia - Modern Pathology - 3 year(s) ago
Little is known about B-lymphoblastic leukemia (B-ALL) that lacks expression of terminal deoxynucleotidyl transferase (TdT). To address this, we performed the largest study to date of TdT-negative B-ALL using data from St. Jude Total XV and XVI clinical trials. Compared to TdT-positive B-ALL (n = 896), TdT-negative B-ALL (n = 21) was associated with younger age (median, 1.4 versus 6.8 years,…
Source: Modern PathologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Tdt-negative pediatric B-lymphoblastic leukemia - Rare, 1-2% of B-ALL cases - Highly associated with KMT2Ar - About 50% are also CD34-neg - May be diagnostically confusing - About 25% express CD10 https://t.co/d2ybfSmBMH #hemepath #hematology #pathology #pediatrics
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Mashup Score: 5Clinicopathological and genomic features in patients with head and neck neuroendocrine carcinoma - Modern Pathology - 3 year(s) ago
Neuroendocrine carcinoma (NEC) of the head and neck is a rare type of malignancy, accounting for only 0.3% of all head and neck cancers, and its clinicopathological and genomic features have not been fully characterized. We conducted a retrospective analysis of 27 patients with poorly differentiated NEC of the head and neck seen at our institution over a period of 15 years. Patient…
Source: Modern PathologyCategories: Latest Headlines, PathologyTweet-
OPEN ACCESS Clinicopathological and genomic features of head and neck neuroendocrine carcinoma https://t.co/0V1uwtfPRp 🌟lower prevalence of TP53 and RB1 mutations than in SCLC 🌟 FGFR3-TACC3 fusion, NOTCH, PI3K/AKT/mTOR potential therapeutic targets https://t.co/aZDDLBuGyk
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Mashup Score: 1Inside the USCAP Journals - Modern Pathology - 3 year(s) ago
Modern Pathology –
Inside the USCAP Journals Source: Modern PathologyCategories: Latest Headlines, PathologyTweet-
RT @histopathology: Inside the USCAP Journals https://t.co/Ql4aRg15Gs
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Mashup Score: 1
Breast implant anaplastic large cell lymphoma (ALCL) is a T-cell neoplasm arising around textured breast implants that was recognized recently as a distinct entity by the World Health Organization. Rarely, other types of lymphoma have been reported in patients with breast implants, raising the possibility of a pathogenetic relationship between breast implants and other types of lymphoma. We…
Source: Modern PathologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Breast implant lymphoma is not always T cell ALCL Epstein–Barr-virus-positive large B-cell lymphoma associated with breast implants: an analysis of eight patients suggesting a possible pathogenetic relationship | Modern Pathology https://t.co/psE0pm97gf
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Mashup Score: 0Spatial immunoprofiling of the intratumoral and peritumoral tissue of renal cell carcinoma patients - 3 year(s) ago
While the abundance and phenotype of tumor-infiltrating lymphocytes are linked with clinical survival, their spatial coordination and its clinical significance remain unclear. Here, we investigated the immune profile of intratumoral and peritumoral tissue of clear cell renal cell carcinoma patients (n = 64). We trained a cell classifier to detect lymphocytes from hematoxylin and eosin stained…
Source: Modern PathologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Spatial immunoprofiling of the intratumoral and peritumoral tissue of renal cell carcinoma patients | Modern Pathology https://t.co/KzLcA9DCT6
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Mashup Score: 0TERT promoter mutation is an objective clinical marker for disease progression in chondrosarcoma - 3 year(s) ago
Chondrosarcomas are the second most common malignant bone tumor. Activating promoter mutations in telomerase reverse transcriptase (TERT) was recently described by us and others as a frequent mutation in high-grade chondrosarcoma. In this study, we investigate the prognostic significance of TERT promoter mutations in 241 chondrosarcomas from 190 patients collected over 24 years (1994–2017). The…
Source: Modern PathologyCategories: Latest Headlines, PathologyTweet-
OPEN ACCESS TERT promoter mutations in chondrosarcoma are easily analyzed and hold promising potential as an objective clinical prognostic marker and as a potential therapeutic target. https://t.co/S1bd7Qo5D7
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Mashup Score: 15Nuclear expression of DDIT3 distinguishes high-grade myxoid liposarcoma from other round cell sarcomas - 3 year(s) ago
Myxoid liposarcoma (MLPS) is a malignant adipocytic neoplasm with predilection for the extremities. MLPS is genetically defined by a t(12;16) translocation leading to FUS–DDIT3 (95%) or more rarely t(12;22) leading to EWSR1–DDIT3. Low-grade MLPS is characterized by bland spindle cells within a myxoid matrix containing delicate “chicken-wire” vasculature, whereas high-grade (“round cell”) MLPS may…
Source: Modern PathologyCategories: Latest Headlines, PathologyTweet-
RT @JLHornick: Next-generation IHC! #PathTwitter #BSTPath @ModernPathology @Greg_Charville @BWHPath https://t.co/10UWRX6Z06
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Mashup Score: 1
Endoscopic therapy is currently the standard of care for the treatment of high-grade dysplasia (HGD) or intramucosal adenocarcinoma (IMC) in patients with Barrett’s esophagus (BE). Visible lesions are treated with endoscopic mucosal resection (EMR), which is often coupled with radiofrequency ablation (RFA). However, endoscopic therapy may require multiple sessions (one session every 2-3 months)…
Source: Modern PathologyCategories: Latest Headlines, PathologyTweet-
OPEN ACCESS https://t.co/SObwfD7SJE Persistent or recurrent Barrett’s neoplasia after an endoscopic therapy session is associated with DNA content abnormality and can be detected by DNA flow cytometric analysis of paraffin-embedded tissue https://t.co/KmjlgPmnem
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Mashup Score: 3
Sentinel lymph node (SN) tumor burden is becoming increasingly important and is likely to be included in future N classifications in melanoma. Our aim was to investigate the prognostic significance of melanoma infiltration of various anatomically defined lymph node substructures. This retrospective cohort study included 1250 consecutive patients with SN biopsy. The pathology protocol required…
Source: Modern PathologyCategories: Latest Headlines, PathologyTweet-
OPEN ACCESS The histopathologic status of the sentinel lymph node is a powerful prognostic factor for patients with primary cutaneous melanomas. These authors developed sentinel node invasion level (SNIL) as non-metric staging system. https://t.co/dvvMkVVXij https://t.co/EcFOWFgupQ
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OPEN ACCESS đź’ĄMonthly Readers' Choiceđź’Ą The genomics of spatially separated regions of multifocal invasive mucinous adenocarcinomas of the lung by whole exome sequencing https://t.co/NUrvC8AqAo https://t.co/tYwz2cN8yO