-
Mashup Score: 0Amphiregulin in intestinal acute graft-versus-host disease: a possible diagnostic and prognostic aid - Modern Pathology - 2 year(s) ago
Amphiregulin, a weak epidermal growth factor receptor agonist, is elevated, while epidermal growth factor, a strong epidermal growth factor receptor agonist, is low in the blood of patients with severe acute graft-versus-host disease. However, the tissue expression and function of these epidermal growth factor receptor ligands in acute graft-versus-host disease target organs is unknown. We…
Source: Modern PathologyCategories: Hematologists1, Latest HeadlinesTweet
-
Mashup Score: 3The clinicopathologic spectrum and genomic landscape of de-/trans-differentiated melanoma - Modern Pathology - 3 year(s) ago
Dedifferentiation and transdifferentiation are rare and only poorly understood phenomena in cutaneous melanoma. To study this disease more comprehensively we have retrieved 11 primary cutaneous melanomas from our pathology archives showing biphasic features characterized by a conventional melanoma and additional areas of de-/trans-differentiation as defined by a lack of immunohistochemical…
Source: Modern PathologyCategories: Latest Headlines, PathologyTweet-
RT @redsnapperpath: Some good reads #dermpath reads in @ModernPathology this month From @TBrennster : https://t.co/DYlvMYs5RZ And some mo…
-
-
Mashup Score: 1Inside the USCAP Journals - Modern Pathology - 3 year(s) ago
Modern Pathology –
Inside the USCAP Journals Source: Modern PathologyCategories: Latest Headlines, PathologyTweet-
RT @histopathology: Inside the USCAP Journals https://t.co/qpQYjUJP78
-
-
Mashup Score: 2
Immunohistochemistry (IHC) and/or MSI-PCR (microsatellite instability-polymerase chain reaction) tests are performed routinely to detect mismatch repair deficiency (MMR-D). Classical MMR-D tumors present a loss of MLH1/PMS2 or MSH2/MSH6 with MSI-High. Other profiles of MMR-D tumors have been described but have been rarely studied. In this study, we established a classification of unusual MMR-D…
Source: Modern PathologyCategories: Latest Headlines, PathologyTweet-
OPEN ACCESS An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes https://t.co/wL2ZzDJKT3 https://t.co/EfZNi8jNO7
-
-
Mashup Score: 5
Since the discovery of an oncogenic tropomyosin-receptor kinase (TRK) fusion protein in the early 1980s, our understanding of neurotrophic tropomyosin-receptor kinase (NTRK) fusions, their unique patterns of frequency in different tumor types, and methods to detect them have grown in scope and depth. Identification of these molecular alterations in the management of patients with cancer has…
Source: Modern PathologyCategories: Latest Headlines, PathologyTweet-
OPEN ACCESS https://t.co/oxd2qagukO By carefully implementing fusion-testing algorithms and selecting optimal testing methodologies, pathologists can greatly improve the utility of TRK inhibitors in patients with cancer and as a result, improve patient outcomes.
-
-
Mashup Score: 67Diagnostic and predictive biomarkers for lymphoma diagnosis and treatment in the era of precision medicine - Modern Pathology - 3 year(s) ago
Lymphomas are a group of hematological malignancies derived from lymphocytes. Lymphomas are clinically and biologically heterogeneous and have overlapping diagnostic features. With the advance of new technologies and the application of efficient and feasible detection platforms, an unprecedented number of novel biomarkers have been discovered or are under investigation at the genetic, epigenetic,…
Source: Modern PathologyCategories: Hematologists1, Latest HeadlinesTweet-
I wish I could draw this from memory https://t.co/etR2lQGtmS https://t.co/l6qWvHZcDy
-
-
Mashup Score: 4
Since the discovery of an oncogenic tropomyosin-receptor kinase (TRK) fusion protein in the early 1980s, our understanding of neurotrophic tropomyosin-receptor kinase (NTRK) fusions, their unique patterns of frequency in different tumor types, and methods to detect them have grown in scope and depth. Identification of these molecular alterations in the management of patients with cancer has…
Source: Modern PathologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Dr. @JackieHechtman (now at @NeoGenomics) wrote an #openaccess review on best practices for identifying NTRK fusions in tumors for #pathologists. https://t.co/dUoAvzzeR4 @OncoAlert https://t.co/9zFyyNA0z4
-
-
Mashup Score: 4Acute lung injury—from cannabis to COVID - Modern Pathology - 3 year(s) ago
Recent world events have refocused attention on the pathology associated with clinical acute respiratory distress syndrome (ARDS). The vast majority of cases of clinical ARDS will have diffuse alveolar damage (DAD) histologically, but other histologies may occur less frequently. The aim of this paper is to provide a review of the pathology of DAD and acute fibrinous and organizing pneumonia and…
Source: Modern PathologyCategories: Hem/Oncs, Latest HeadlinesTweet-
Acute lung injury (ALI) - from cannabis to #Ecigs to #COVID19 An #openaccess review by Dr. Mary Beth Beasley @MountSinai_Path https://t.co/wEiTSwCIYU The most common histopathological manifestation of ALI/ARDS is diffuse alveolar damage (DAD) but other pathologies can also occur https://t.co/ecwY2eYfDI
-
-
Mashup Score: 5Image-based assessment of extracellular mucin-to-tumor area predicts consensus molecular subtypes (CMS) in colorectal cancer - Modern Pathology - 3 year(s) ago
The backbone of all colorectal cancer classifications including the consensus molecular subtypes (CMS) highlights microsatellite instability (MSI) as a key molecular pathway. Although mucinous histology (generally defined as >50% extracellular mucin-to-tumor area) is a “typical” feature of MSI, it is not limited to this subgroup. Here, we investigate the association of CMS classification and…
Source: Modern PathologyCategories: Latest Headlines, PathologyTweet-
OPEN ACCESS Image-based assessment of extracellular mucin-to-tumor area predicts consensus molecular subtypes (CMS) in colorectal cancer #GIpath https://t.co/SQ7VMmyGpI https://t.co/FOZ44i39NW
-
-
Mashup Score: 6Inside the USCAP Journals - Modern Pathology - 3 year(s) ago
Modern Pathology –
Inside the USCAP Journals Source: Modern PathologyCategories: Latest Headlines, PathologyTweet-
https://t.co/5D9TREvkvj "Inside the USCAP Journals" for Sept ✅DICER1 mutations in embryonal rhabdomyosarcomas of the uterine corpus ✅Supporting pathologists with automated IHC requests ✅Tools to distinguish rare adenocarcinomas ✅DNA repair in radiotherapy resistance and more
-
One source of circulating amphiregulin may be release from the GI tract: https://t.co/JZYOtV8ZGa