• Mashup Score: 0

    A 26-year-old woman presented with a chief complaint of recurrent upper respiratory and sinus infections. She reported that during the last 2 years, she had experienced 4 sinus infections lasting longer than 1 week requiring antibiotic therapy and multiple sinopulmonary infections during the spring and fall. Before this, she denied any history of recurrent sinus infection, upper respiratory tract…

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    • The patient reported that during the last 2 years, she had experienced 4 sinus infections lasting longer than 1 week requiring antibiotic therapy and multiple sinopulmonary infections during the spring and fall. https://t.co/cBzBqGPzTr https://t.co/KxsI5syuC2

  • Mashup Score: 0

    Bringing a unique dual expertise in clinical medicine and biomedical investigation, the clinical investigator contributes indispensably to the research enterprise of medicine. The continuation of such contributions is dependent on the recruitment of nascent clinical investigators and their subsequent maturation into independent, productive, and funded participants in the research community at…

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    • The careers of clinical investigators need to be vigorously promoted, supported, and safeguarded intramurally and extramurally. https://t.co/mQapFbXWzl https://t.co/I7ba4dxKUs

  • Mashup Score: 1

    Magnesium disorders are common in clinical practice and when present can manifest clinically as cardiovascular, neuromuscular, or other organ dysfunction. Hypomagnesemia is far more common than hypermagnesemia, which is largely seen in patients with reduced glomerular filtration rates receiving magnesium-containing medications. In addition to inherited disorders of magnesium handling,…

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    • An understanding of the physiology of renal and intestinal magnesium handling allows for an understanding of the etiologies and therapies of hypomagnesemia and other magnesium disorders that can have protean clinical manifestations. https://t.co/JsDE3Iqjy3 https://t.co/wr3CV3mSNS

  • Mashup Score: 0

    Bringing a unique dual expertise in clinical medicine and biomedical investigation, the clinical investigator contributes indispensably to the research enterprise of medicine. The continuation of such contributions is dependent on the recruitment of nascent clinical investigators and their subsequent maturation into independent, productive, and funded participants in the research community at…

    Tweet Tweets with this article
    • The careers of clinical investigators need to be vigorously promoted, supported, and safeguarded intramurally and extramurally. https://t.co/7W0nlHuosN https://t.co/Kx69zQRwxm

  • Mashup Score: 21

    Recently, the US Food and Drug Administration (FDA) approved selinexor for patients with multiple myeloma, overruling the final vote of the Oncology Drug Advisory Committee (ODAC). Several oncologists voiced criticism of this approval, citing marginal objective response rate, largely partial response, and considerable toxicity.1,2

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    • Ha. Even the meeting hardly matters. When they vote: Yes, they approve, when they vote: No, they approve often. They have to approve a lot so that when they quit the FDA they'll get good jobs at the companies. See paper https://t.co/p9mW085flI https://t.co/b8dVO9pZoD