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Mashup Score: 0Oxidation modulates LINGO2-induced inactivation of large conductance, Ca2+-activated potassium channels - 1 year(s) ago
Ca2+ and voltage-activated K+ (BK) channels are ubiquitous ion channels that can be modulated by accessory proteins, including β, γ, and LINGO1 BK subunits. In this study, we utilized a combination of site-directed mutagenesis, patch clamp electrophysiology, and molecular modeling to investigate if the biophysical properties of BK currents were affected by coexpression of LINGO2 and to examine…
Source: Journal of Biological ChemistryCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 0
Iron accumulates with age in mammals, and its possible implications in altering metabolic responses are not fully understood. Here, we report that both high-iron diet and advanced age in mice consistently altered gene expression of many pathways, including those governing the oxidative stress response and the circadian clock. We used a metabolomic approach to reveal similarities between metabolic…
Source: Journal of Biological ChemistryCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 0
Iron accumulates with age in mammals, and its possible implications in altering metabolic responses are not fully understood. Here, we report that both high-iron diet and advanced age in mice consistently altered gene expression of many pathways, including those governing the oxidative stress response and the circadian clock. We used a metabolomic approach to reveal similarities between metabolic…
Source: Journal of Biological ChemistryCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 0Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I - 1 year(s) ago
Mitochondrial complex I (NADH:ubiquinone oxidoreductase), a crucial enzyme in energy metabolism, captures the redox potential energy from NADH oxidation/ubiquinone reduction to create the proton motive force used to drive ATP synthesis in oxidative phosphorylation. High-resolution single-particle electron cryo-EM analyses have provided detailed structural knowledge of the catalytic machinery of…
Source: Journal of Biological ChemistryCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 1Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I - 1 year(s) ago
Mitochondrial complex I (NADH:ubiquinone oxidoreductase), a crucial enzyme in energy metabolism, captures the redox potential energy from NADH oxidation/ubiquinone reduction to create the proton motive force used to drive ATP synthesis in oxidative phosphorylation. High-resolution single-particle electron cryo-EM analyses have provided detailed structural knowledge of the catalytic machinery of…
Source: Journal of Biological ChemistryCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 0A redox cycle with complex II prioritizes sulfide quinone oxidoreductase-dependent H2S oxidation - 1 year(s) ago
The dual roles of H2S as an endogenously synthesized respiratory substrate and as a toxin raise questions as to how it is cleared when the electron transport chain is inhibited. Sulfide quinone oxidoreductase (SQOR) catalyzes the first step in the mitochondrial H2S oxidation pathway, using CoQ as an electron acceptor, and connects to the electron transport chain at the level of complex III. We…
Source: Journal of Biological ChemistryCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 0A redox cycle with complex II prioritizes sulfide quinone oxidoreductase-dependent H2S oxidation - 1 year(s) ago
The dual roles of H2S as an endogenously synthesized respiratory substrate and as a toxin raise questions as to how it is cleared when the electron transport chain is inhibited. Sulfide quinone oxidoreductase (SQOR) catalyzes the first step in the mitochondrial H2S oxidation pathway, using CoQ as an electron acceptor, and connects to the electron transport chain at the level of complex III. We…
Source: Journal of Biological ChemistryCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 0A redox cycle with complex II prioritizes sulfide quinone oxidoreductase-dependent H2S oxidation - 1 year(s) ago
The dual roles of H2S as an endogenously synthesized respiratory substrate and as a toxin raise questions as to how it is cleared when the electron transport chain is inhibited. Sulfide quinone oxidoreductase (SQOR) catalyzes the first step in the mitochondrial H2S oxidation pathway, using CoQ as an electron acceptor, and connects to the electron transport chain at the level of complex III. We…
Source: Journal of Biological ChemistryCategories: Genetics, Latest HeadlinesTweet
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Mashup Score: 0
Abiraterone acetate is a first-line therapy for castration-resistant prostate cancer. This prodrug is deacetylated in vivo to abiraterone, which is a potent and specific inhibitor of cytochrome P450 17A1 (CYP17A1). CYP17A1 performs two sequential steps that are required for the biosynthesis of androgens that drive prostate cancer proliferation analogous to estrogens in breast cancer. Abiraterone…
Source: Journal of Biological ChemistryCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Intracellular zinc protects Kv7 K+ channels from Ca2+/calmodulin-mediated inhibition - 1 year(s) ago
Zinc (Zn) is an essential trace element; it serves as a cofactor for a great number of enzymes, transcription factors, receptors, and other proteins. Zinc is also an important signaling molecule, which can be released from intracellular stores into the cytosol or extracellular space, for example, during synaptic transmission. Amongst cellular effects of zinc is activation of Kv7 (KCNQ, M-type)…
Source: Journal of Biological ChemistryCategories: Latest Headlines, NeurologyTweet
Dudem et al.'s molecular modeling suggests that methionine oxidation reduces the lipophilicity of the tail, thus preventing it from occluding the pore of the voltage-activated K+ (BK) channel. https://t.co/sjuaOa6QMJ