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Mashup Score: 3Association of knee atypical lesions with foot ulcers and a peak of kappa IgM monoclonal immunoglobulin - 1 year(s) ago
An 84-year-old man presented with small erythematous, necrotic papules on the knees (Fig 1) and the dorsal side of hands, associated with 2 plantar ulcers and paraesthesias. Pancytopenia and a peak of kappa IgM monoclonal immunoglobulin (28.3 g/L), with free kappa light chains, were noted. A Bence-Jones kappa-like proteinuria was present. Bone marrow aspirate analysis revealed a B-cell…
Source: JAAD Case ReportsCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 0JAK-inhibitors as rescue therapy in dupilumab-refractory severe atopic dermatitis: A case series of 6 patients - 1 year(s) ago
Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disorder with a heterogeneous clinical presentation and the cardinal symptom of itch, that results in significant patient burden and a significant decrease in patient’s quality of life.1 The pathogenesis of AD is multifactorial and results from an immune response skewed toward the Th2 axis, displaying upregulation of key cytokines,…
Source: JAAD Case ReportsCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 0
Acute inflammatory edema (AIE) is a non-infectious pseudocellulitis that was initially described by Marchione et al1 in a case series of 15 patients in 2019. AIE typically presents as bilateral blanchable, erythematous, and edematous plaques in predisposed patients. AIE tends to be localized to the thighs, lower abdomen, and flanks in a dependent, pressure-sparing distribution.2 Given the paucity…
Source: JAAD Case ReportsCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 7Complete response to dupilumab in a patient with chronic spontaneous urticaria who did not tolerate omalizumab - 1 year(s) ago
Chronic spontaneous urticaria (CSU) is characterized by mast cell-driven wheals, angioedema, or both. Two endotypes of CSU have been identified, ie, autoallergic and autoimmune CSU. The latter comes with high disease activity as well as poor response to antihistamine and omalizumab treatment.1 Dupilumab was recently demonstrated to be effective in patients with antihistamine-resistant CSU.2 Here,…
Source: JAAD Case ReportsCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 2Minocycline induced drug rash with eosinophilia and systemic symptoms complicated by hemophagocytic lymphohistiocytosis - 1 year(s) ago
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome, also known as drug-induced hypersensitivity syndrome, is a severe, potentially life-threatening, complex hypersensitivity reaction occurring typically 1-6 weeks after exposure to certain medications or their metabolites. Estimates of overall population risk are between 1 in 1000 to 1 in 10,000 drug exposures.1 It is classically…
Source: JAAD Case ReportsCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 2Spontaneous resolution of intractable prurigo nodularis after subinsular cortex stroke - 1 year(s) ago
Prurigo nodularis (PN) is a chronic skin condition characterized by the formation of cutaneous nodules caused by repetitive scratching. Pathogenesis of PN implicates dysregulation of neuroimmunologic circuits that potentiate the itch-scratch cycle.1 Development of unilateral PN after contralateral strokes in various brain regions have been reported,2,3 suggesting a role of the central nervous…
Source: JAAD Case ReportsCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 1
Digitate keratoses (DK) are a heterogenous group of inherited or acquired disorders of keratinization.1,2 These rare entities are characterized by digitate spiked keratotic papules that can be both follicular and non-follicular in origin.1-3 DK have multiple clinical presentations, resulting in confusion and debate in the literature. Caccetta et al3 suggested a classification and diagnosis…
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Mashup Score: 0Figurate urticaria as a presenting sign of Capnocytophaga canimorsus bacteremia after dog bite - 1 year(s) ago
Capnocytophaga canimorsus is a Gram-negative, fastidious bacillus found in the oral flora of dogs and, less commonly, cats. The first reported case of C. canimorsus infection was published in 1976, and there have been nearly 500 more since.1 Many patients have cutaneous manifestations, most commonly petechiae, purpura, gangrene, and cellulitis.2 We describe a rare case of C. canimorsus bacteremia…
Source: JAAD Case ReportsCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 1A patient with chronic bilateral periauricular swelling - 1 year(s) ago
A 49-year-old female with a history of atopic dermatitis and asthma was referred to our dermatology clinic for chronic pruritic swelling of both sides of her face. Review of symptoms was negative for fever, weight changes, and night sweats. Physical examination revealed ill-defined, nontender, subcutaneous bilateral periauricular swelling (Fig 1, A and B). Laboratory testing revealed high…
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Mashup Score: 1Angioinvasive mucormycosis in a patient with aplastic anemia - 1 year(s) ago
A 9-year-old boy with no past medical history was admitted for severe epistaxis and aplastic anemia of unknown etiology with hospital course complicated by bacteremia and the development of a tender plaque on the forearm. Exam revealed a violaceous plaque with peripheral erythema and central necrosis on the left dorsal forearm (Fig 1). Punch biopsies for frozen section and tissue cultures were…
Source: JAAD Case ReportsCategories: Dermatology, Latest HeadlinesTweet
An 84-year-old man presented with small erythematous, necrotic papules on the knees and the dorsal side of hands, associated with 2 plantar ulcers and paraesthesias. Pancytopenia and a peak of kappa IgM monoclonal immunoglobulin (28.3 g/L)...https://t.co/k9PqjQ184c