• Mashup Score: 3

    An 84-year-old man presented with small erythematous, necrotic papules on the knees (Fig 1) and the dorsal side of hands, associated with 2 plantar ulcers and paraesthesias. Pancytopenia and a peak of kappa IgM monoclonal immunoglobulin (28.3 g/L), with free kappa light chains, were noted. A Bence-Jones kappa-like proteinuria was present. Bone marrow aspirate analysis revealed a B-cell…

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    • An 84-year-old man presented with small erythematous, necrotic papules on the knees and the dorsal side of hands, associated with 2 plantar ulcers and paraesthesias. Pancytopenia and a peak of kappa IgM monoclonal immunoglobulin (28.3 g/L)...https://t.co/k9PqjQ184c

  • Mashup Score: 0

    Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disorder with a heterogeneous clinical presentation and the cardinal symptom of itch, that results in significant patient burden and a significant decrease in patient’s quality of life.1 The pathogenesis of AD is multifactorial and results from an immune response skewed toward the Th2 axis, displaying upregulation of key cytokines,…

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    • This case series describes the use of JAK inhibitors as rescue therapy for flares of atopic dermatitis on dupilumab. This was successful in controlling the flare in all of the cases described and no rebound flares were observed. https://t.co/ApZyT0xNly https://t.co/5wMepvDfTx

  • Mashup Score: 0

    Acute inflammatory edema (AIE) is a non-infectious pseudocellulitis that was initially described by Marchione et al1 in a case series of 15 patients in 2019. AIE typically presents as bilateral blanchable, erythematous, and edematous plaques in predisposed patients. AIE tends to be localized to the thighs, lower abdomen, and flanks in a dependent, pressure-sparing distribution.2 Given the paucity…

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    • A 55-year-old man with a history of Crohn’s disease and end-stage interstitial lung disease was admitted for bilateral lung transplantation. His immediate postoperative course was complicated by thoracic compartment syndrome and allograft dysfunction...https://t.co/GocsGZIMZ0

  • Mashup Score: 7

    Chronic spontaneous urticaria (CSU) is characterized by mast cell-driven wheals, angioedema, or both. Two endotypes of CSU have been identified, ie, autoallergic and autoimmune CSU. The latter comes with high disease activity as well as poor response to antihistamine and omalizumab treatment.1 Dupilumab was recently demonstrated to be effective in patients with antihistamine-resistant CSU.2 Here,…

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    • Complete response to dupilumab in a patient with chronic spontaneous #urticaria who did not tolerate omalizumab. Learn more in JAAD Case Reports -https://t.co/dsuSBqznzd https://t.co/MZ0obXlPiN

  • Mashup Score: 2

    Prurigo nodularis (PN) is a chronic skin condition characterized by the formation of cutaneous nodules caused by repetitive scratching. Pathogenesis of PN implicates dysregulation of neuroimmunologic circuits that potentiate the itch-scratch cycle.1 Development of unilateral PN after contralateral strokes in various brain regions have been reported,2,3 suggesting a role of the central nervous…

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    • A 56-year-old man presented to the dermatology clinic with a >15 year history of severe #pruritus on the bilateral upper portion of the back and neck with >50 excoriated, hyperpigmented, hyperkeratotic and lichenified papules/nodules consistent with PN... https://t.co/AC3gH5ExQa

  • Mashup Score: 1

    Digitate keratoses (DK) are a heterogenous group of inherited or acquired disorders of keratinization.1,2 These rare entities are characterized by digitate spiked keratotic papules that can be both follicular and non-follicular in origin.1-3 DK have multiple clinical presentations, resulting in confusion and debate in the literature. Caccetta et al3 suggested a classification and diagnosis…

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    • Infantile anogenital digitate keratoses is a benign condition that spontaneously resolves. This case series describes seven cases of IADK. https://t.co/PJI8L5u1gL https://t.co/U3SenNJ7xi

  • Mashup Score: 1

    A 49-year-old female with a history of atopic dermatitis and asthma was referred to our dermatology clinic for chronic pruritic swelling of both sides of her face. Review of symptoms was negative for fever, weight changes, and night sweats. Physical examination revealed ill-defined, nontender, subcutaneous bilateral periauricular swelling (Fig 1, A and B). Laboratory testing revealed high…

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    • A 49-year-old female with a history of #atopicdermatitis and asthma was referred to our dermatology clinic for chronic pruritic swelling of both sides of her face. Review of symptoms was negative for fever, weight changes, and night sweats... https://t.co/Frs02KiFYE

  • Mashup Score: 1

    A 9-year-old boy with no past medical history was admitted for severe epistaxis and aplastic anemia of unknown etiology with hospital course complicated by bacteremia and the development of a tender plaque on the forearm. Exam revealed a violaceous plaque with peripheral erythema and central necrosis on the left dorsal forearm (Fig 1). Punch biopsies for frozen section and tissue cultures were…

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    • Angioinvasive mucormycosis in a patient with aplastic anemia #dermtwitter https://t.co/591f5nEV29