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Mashup Score: 36Update in the molecular classification of endometrial carcinoma - 10 hour(s) ago
The pathological classification of endometrial carcinomas, one of the cornerstones in patient clinical management, has traditionally been based on morphologic features. However, this classification system does not fully reflect the biological diversity of endometrial carcinomas and has limited reproducibility. In the last decade, several studies have reported the strong prognostic value of the molecular endometrial carcinoma subgroups and, more recently, its potential to inform adjuvant treatment decisions. This has in turn resulted in a transition from a purely morphological classification towards an integrated histological and molecular system in the latest World Health Organization (WHO) classification of tumors of female reproductive organs. The new European treatment guidelines combine the molecular subgroups with traditional clinicopathological features in order to guide treatment decision-making. Accurate molecular subgroup assignment is therefore essential for adequate patient
Source: ijgc.bmj.comCategories: General Medicine News, Oncologists2Tweet
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Mashup Score: 6Neuroendocrine neoplasms of the ovary: a review of 63 cases - 4 day(s) ago
Objective To describe the clinicopathological characteristics and survival outcomes of ovarian neuroendocrine neoplasms from a curated registry. Methods This is a retrospective cross-sectional study of patients in our registry with confirmed ovarian neuroendocrine neoplasms. We excluded patients with small cell carcinoma not otherwise specified, small cell hypercalcemic type, and those with neuroendocrine ‘features’ or ‘differentiation.’ Clinicopathological characteristics were described in two separate groups: patients with carcinoid tumors and patients with neuroendocrine carcinomas. Progression-free and overall survival were estimated with the Kaplan-Meier product-limit estimator in these two groups, and multivariable analysis was done to identify predictors of survival for neuroendocrine carcinomas only. Results A total of 63 patients met inclusion criteria, 13 (21%) with carcinoid tumors and 50 (79%) with neuroendocrine carcinomas. In the carcinoid tumor group, one patient (8%) wa
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Mashup Score: 11Role of endometrial sampling to differentiate between advanced endometrial versus ovarian malignancy: retrospective cohort study - 11 day(s) ago
Objective Distinguishing between advanced stage endometrial and ovarian cancer at diagnosis can be challenging, especially when patients do not present with abnormal uterine bleeding. Given emerging systemic therapies specific for ovarian versus endometrial cancers, it has become increasingly critical to establish the correct diagnosis at presentation to ensure appropriate treatment. This study evaluates the frequency with which advanced endometrial cancer is mistakenly presumed to be ovarian cancer. Methods A retrospective analysis was performed of patients with a final diagnosis of advanced endometrial cancer treated consecutively at a single academic institution between 2013 and 2022. Variables abstracted included abnormal uterine bleeding, endometrial sampling, and timing of endometrial cancer diagnosis. We quantified incorrect diagnoses made after 2018, when frontline targeted treatments differentiating advanced endometrial from advanced ovarian cancer became available. Results We
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Mashup Score: 6
Objective Lymph nodal involvement is a prognostic factor in endometrial cancer. The added value of para-aortic lymphadenectomy compared with pelvic nodal evaluation alone remains a matter of debate in the management of patients with intermediate- and high-risk endometrial cancer. A systematic review and meta-analysis was conducted to assess the prognostic value of para-aortic lymphadenectomy in terms of overall survival and disease-free survival in patients with intermediate- and high-risk endometrial cancer. Methods The study adhered to the PRISMA guidelines. PubMed, Google Scholar and ClinicalTrials.gov were searched from January 2000 to April 2023. Studies on intermediate- and high-risk patients who underwent pelvic versus pelvic and para-aortic dissection were included in the analysis. The Methodological Index for Nonrandomized Studies (MINORS) and the Quality Assessment of Diagnostic Accuracy Studies 2 tool (QUADAS-2) were used for quality assessment of the selected articles. Resu
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Mashup Score: 18Consensus on surgical technique for sentinel lymph node dissection in cervical cancer - 18 day(s) ago
Objective The purpose of this study was to establish a consensus on the surgical technique for sentinel lymph node (SLN) dissection in cervical cancer. Methods A 26 question survey was emailed to international expert gynecological oncology surgeons. A two-step modified Delphi method was used to establish consensus. After a first round of online survey, the questions were amended and a second round, along with semistructured interviews was performed. Consensus was defined using a 70% cut-off for agreement. Results Twenty-five of 38 (65.8%) experts responded to the first and second rounds of the online survey. Agreement ≥70% was reached for 13 (50.0%) questions in the first round and for 15 (57.7%) in the final round. Consensus agreement identified 15 recommended, three optional, and five not recommended steps. Experts agreed on the following recommended procedures: use of indocyanine green as a tracer; superficial (with or without deep) injection at 3 and 9 o’clock; injection at the mar
Source: ijgc.bmj.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 9Ovarian cancer during fertility follow-up - 22 day(s) ago
A patient in her 30s with a 2-year history of infertility underwent serial ultrasound monitoring to assess follicular development for pregnancy planning. During the evaluation a previously non-existent lesion was identified in the left ovary, characterized by a 2.5 cm solid multilocular lesion
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Mashup Score: 11Update on near infrared imaging technology: indocyanine green and near infrared technology in the treatment of gynecologic cancers - 1 month(s) ago
In 2020, we published a comprehensive update on the use of fluorescence imaging systems in gynecologic cancer surgery.[1][1] The objective of the current review is to present recent advances in the use of near-infrared (NIR) imaging with indocyanine green (ICG) specific to ureter visualization,
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Mashup Score: 9The art of bowel surgery in gynecologic cancer - 1 month(s) ago
The field of gynecologic oncology has witnessed a profound transformation in the practice of bowel resection over the years. This evolution, driven by innovative techniques and expanded surgical skills, has redefined the role of the surgeon. This review article delves into the historical journey of bowel surgery, its contemporary importance in cytoreductive procedures for gynecologic cancers, and the general principles of digestive surgery. From pioneering surgeons such as Lane, Broca, and Billroth to the introduction of mechanical staplers, this narrative unfolds the remarkable advances in the field. It highlights the critical need for meticulous training, anatomic mastery, aseptic measures, vascular support, tension-free anastomoses, and precise surgical techniques. These principles underpin the success of bowel resection and anastomosis in the complex landscape of gynecologic oncology.
Source: ijgc.bmj.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 11Update on near infrared imaging technology: indocyanine green and near infrared technology in the treatment of gynecologic cancers - 1 month(s) ago
In 2020, we published a comprehensive update on the use of fluorescence imaging systems in gynecologic cancer surgery.[1][1] The objective of the current review is to present recent advances in the use of near-infrared (NIR) imaging with indocyanine green (ICG) specific to ureter visualization,
Source: ijgc.bmj.comCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 11Update on near infrared imaging technology: indocyanine green and near infrared technology in the treatment of gynecologic cancers - 1 month(s) ago
In 2020, we published a comprehensive update on the use of fluorescence imaging systems in gynecologic cancer surgery.[1][1] The objective of the current review is to present recent advances in the use of near-infrared (NIR) imaging with indocyanine green (ICG) specific to ureter visualization,
Source: ijgc.bmj.comCategories: General Medicine News, Onc News and JournalsTweet
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