How should we interpret the results of the major recent trials? What is the impact on clinical practice? How can we design and conduct better and cheaper trials that address true unmet needs? How can we improve operating procedures and streamline trial execution? How to operate within the regulatory environment? Foster cross-talk with regulatory agencies? And more generally, how to create better and safer methods for treating cardiovascular disease? The Global CardioVascular Clinical Trialists Forum (CVCT) is dedicated to the discussion of clinical trials in cardiovascular disease and aims to provide answers to these questions. CVCT meetings are unique, bringing together a carefully selected faculty of opinion leaders, clinical trialists, investigators, regulators, statisticians, industry R&D experts, decision makers and practitioners. Over the years CVCT has attracted audience from over 30 different countries, with participants coming from Western and Eastern Europe, the USA, South Am