• Mashup Score: 7

    Aims/hypothesis Higher plasma concentrations of tumour necrosis factor receptor (TNFR)-1, TNFR-2 and kidney injury molecule-1 (KIM-1) have been found to be associated with higher risk of kidney failure in individuals with type 2 diabetes in previous studies. Whether drugs can reduce these biomarkers is not well established. We measured these biomarkers in samples of the CANVAS study and examined…

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    • In people with diabetes, SGLT2 inhibition attenuated increases in TNFR-1&2 and decreased KIM-1 over time, which are markers of inflammation and fibrosis Our biomarker study from CANVAS with @KidneydrChirag & @scoca1 published in @DiabetologiaJnl https://t.co/Bs7nVetzl5 https://t.co/EapnAidFlN

  • Mashup Score: 7

    Globally, the proportion of new diagnoses of youth-onset diabetes represented by type 2 diabetes is increasing, and youth with type 2 diabetes commonly have complications and comorbidities, as well as a higher rate of mortality. In this review, we summarise what is known about the natural progression of youth-onset type 2 diabetes from published clinical trials and large-scale prospective…

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    • Youth-onset type 2 #diabetes : translating epidemiology into clinical trials. More important is the political decisions to promote healthy lifestyle at school and in families. Main is linked to #obesity and physical #inactivity https://t.co/cMWMJhUx0y

    • Youth-onset type 2 #diabetes : translating epidemiology into clinical trials. More important is the political decisions to promote healthy lifestyle at school and in families. Main is linked to #obesity and physical #inactivity https://t.co/cMWMJhUx0y

  • Mashup Score: 4

    Aims/hypothesis People with obesity and a normal metabolic profile are sometimes referred to as having ‘metabolically healthy obesity’ (MHO). However, whether this group of individuals are actually ‘healthy’ is uncertain. This study aims to examine the associations of MHO with a wide range of obesity-related outcomes. Methods This is a population-based prospective cohort study of 381,363 UK…

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    • Fat but Fit. ‘metabolically healthy obesity’ is a myth! Obese individuals(BMI ≥ 30 kg/m2)who regularly exercise are at an increased risk of heart disease, T2 diabetes and respiratory diseases irrespective of their metabolic profile. https://t.co/5eOPrQBXtF #weightloss https://t.co/bdglJvnMUu