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Mashup Score: 11A systematic review of clinical and preclinical evidences for Janus kinase inhibitors in large vessel vasculitis - Clinical Rheumatology - 4 year(s) ago
Abstract Corticosteroid-sparing disease-modifying anti-rheumatic drugs are an area of active exploration in large vessel vasculitis (LVV), i.e., Takayasu arteritis (TAK) and Giant Cell Arteritis (GCA). The role of Janus kinase (JAK) inhibitors has been recently identified in different inflammatory rheumatic diseases. We conducted a systematic review of the use of JAK inhibitors in LVV across…
Source: Clinical RheumatologyCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0Post-operative outcomes of inflammatory thoracic aortitis: a study of 41 patients from a cohort of 1119 surgical cases - Clinical Rheumatology - 4 year(s) ago
Aortitis is found in 2–12% of thoracic aortic aneurysm repair/replacement surgeries. Yet little is known about such patients’ post-operative outcomes or the role of post-operative corticosteroids. The study was undertaken across three tertiary referral hospitals in Sydney, Australia. Prospectively collected data for all thoracic aortic repair/replacement patients between 2004 and 2018 was…
Source: Clinical RheumatologyCategories: Latest Headlines, RheumatologyTweet-
1119 thoracic aortic surgeries - 3.7% dx as inflammatory aortitis (66% CIA, 27% GCA, 5% TAK) (20% given steroids). Aortitis were more female, older, more HTN w/ more immunosuppressives, but no diff in 30d mortality (7.3 vs 6.5%) https://t.co/94VBaRAry5
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Mashup Score: 14Refractory fibromyalgia - Clinical Rheumatology - 4 year(s) ago
In the medical literature, there are only a few references on refractory fibromyalgia and there is no consensus definition available on this concept. Some definitions of refractory fibromyalgia have been proposed based on the lack of response to a number of medications, and perhaps the most appropriate term is treatment-refractory fibromyalgia. To achieve the definition of treatment-refractory…
Source: Clinical RheumatologyCategories: Latest Headlines, RheumatologyTweet-
📌Refractory fibromyalgia or treatment-refractory fibromyalgia❓ 📌Fibromyalgia refractory to treatment or mistake in diagnosis❓ In this article, the authors propose the bases on which refractory #fibromyalgia could be defined. 👉https://t.co/giQKFxqu8L https://t.co/h8sMxDiNcn
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Mashup Score: 0
This narrative review provides an overview of diffuse alveolar hemorrhage (DAH) associated with rheumatologic and autoimmune diseases and their differentiation from idiopathic pulmonary hemosiderosis (IPH). Relevant immunologic diseases associated with DAH are discussed, and a diagnostic flowchart is proposed to establish a “definitive” diagnosis of IPH within the spectrum of DAH. IPH is a rare…
Source: Clinical RheumatologyCategories: Latest Headlines, RheumatologyTweet-
NEW 🔥🔥Diagnostic approach to patients with diffuse alveolar hemorrhage: idiopathic pulmonary hemosiderosis, anti-GBM disease or vasculitis? 👉https://t.co/9HRoPuUpq5 https://t.co/JdwqLDxQj9
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Mashup Score: 7Impact of smoking habit on adult-onset Still’s disease prognosis, findings from a multicentre observational study - Clinical Rheumatology - 4 year(s) ago
The objective of this study is to describe the possible prognostic impact of smoking habit on adult-onset Still’s disease (AOSD) patients, by the assessment of clinical characteristics, life-threatening complications occurrence, and mortality in smokers than non-smokers. A multicentre retrospective study of prospectively followed-up AOSD patients included in Gruppo Italiano di Ricerca in…
Source: Clinical RheumatologyCategories: Healthcare Professionals, Latest HeadlinesTweet-
Smoking worsens adult-onset Still’s disease. 185 AOSD pts, found 45 smokers who had higher risk of pericarditis (36 vs 16%), pleuritis (33 vs 14%), abd pain (18% vs 6%), higher systemic score (6.4 vs 5.4 ), More MAS (29% vs 6%), lung disease (18% vs 13%) https://t.co/ZKKhw1EbnD
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Mashup Score: 4Hiker’s feet - Clinical Rheumatology - 4 year(s) ago
Clinical Rheumatology –
Source: Clinical RheumatologyCategories: Healthcare Professionals, Latest HeadlinesTweet-
ICYMI: “Hiker’s feet” newly proposed cutaneous foot manifestations of dermatomyositis. Most pts had the antisynthetase syndrome (with anti-Jo-1) and almost all had mechanic’s hands. Such findings should prompt a search for ILD https://t.co/98EAQUHJbz https://t.co/Cw6rSIUyW2
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Mashup Score: 8The use of secukinumab in an HIV-positive patient with axial spondyloarthritis: a case-based review - Clinical Rheumatology - 4 year(s) ago
Axial spondyloarthritis in HIV-positive patients raises specific treatment challenges as immunosuppressant and immunomodulating agents may adversely affect the course of the HIV infection and could increase the risk of opportunistic infections. The efficacy and safety of secukinumab in patients with HIV is unknown due to HIV patients were largely excluded from clinical trials and nowadays, the…
Source: Clinical RheumatologyCategories: Healthcare Professionals, Latest HeadlinesTweet-
ICYMI: Secukinumab (IL-17 inhibitors) can be safely used in HIV spondyloarthritis patients. https://t.co/hpCRJkR9w7 https://t.co/qwbrvGkriX
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Mashup Score: 59Hiker’s feet - Clinical Rheumatology - 4 year(s) ago
Clinical Rheumatology –
Source: Clinical RheumatologyCategories: Latest Headlines, RheumatologyTweet-
“Hiker’s feet” newly proposed cutaneous foot manifestations of dermatomyositis. Most pts had the antisynthetase syndrome (with anti-Jo-1) and almost all had mechanic’s hands. Such findings should prompt a search for ILD https://t.co/98EAQUHJbz https://t.co/mJ467Nfe8T
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Mashup Score: 22The use of secukinumab in an HIV-positive patient with axial spondyloarthritis: a case-based review - Clinical Rheumatology - 4 year(s) ago
Axial spondyloarthritis in HIV-positive patients raises specific treatment challenges as immunosuppressant and immunomodulating agents may adversely affect the course of the HIV infection and could increase the risk of opportunistic infections. The efficacy and safety of secukinumab in patients with HIV is unknown due to HIV patients were largely excluded from clinical trials and nowadays, the…
Source: Clinical RheumatologyCategories: Latest Headlines, RheumatologyTweet-
Secukinumab (IL-17 inhibitors) can be safely used in HIV spondyloarthritis patients. https://t.co/hpCRJkR9w7
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Mashup Score: 8A narrative review of imaging in calcinosis associated with systemic sclerosis - Clinical Rheumatology - 4 year(s) ago
Calcinosis is dystrophic calcification of the soft tissue which can lead to painful and debilitating disease. It is commonly seen in patients with systemic sclerosis (SSc). Imaging can assist in diagnosis, quantification of disease, and better pathophysiologic understanding of calcinosis. Traditionally, X-rays have been the most frequently used imaging modality for diagnosis; however, advances in…
Source: Clinical RheumatologyCategories: Latest Headlines, RheumatologyTweet-
A comprehensive review on #imaging in #calcinosis associated with #SystemicSclerosis 👉https://t.co/6Hl7WnGBhi #RheumTwitter #MedTwitter #MedEd https://t.co/p3BadbTona
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A NEW systematic review of #JAKinhibitors in LV #vasculitis 📌Tofacitinib is associated with better outcomes than MTX in TAK 📌JAKinibs reduce adventitial fibrosis, intimal proliferation, inflammatory vascular infiltrate in pre-clinical models of LVV 👉https://t.co/ZZuMVh072F https://t.co/VKjQ8blf2w