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Mashup Score: 9
Ocular adverse events are common to many antineoplastic agents, although often misunderstood. In most cases, they are easily manageable, but sometimes they require instrumental diagnostics and specific treatments. There are currently no international guidelines for the management of these toxicities. In this review we summarized the main ocular adverse events related to the antineoplastic agents…
Source: Clinical Breast CancerCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Breast cancer is the second most common cause of brain metastases (BM) in women, with rates varying by subtype, but reaching 30-50% in those with HER2-positive metastatic breast cancer (MBC)1, 2. The presence of BM is associated with worse outcomes, but there is significant variability in prognosis3. Advances in systemic therapy have significantly improved outcomes for patients with HER2+ BC, but…
Source: Clinical Breast CancerCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 2Molecular Classification of Triple Negative Breast Cancer and the Emergence of Targeted Therapies - 2 year(s) ago
Triple negative breast cancer (TNBC) represents 15% to 20% of all primary breast cancers and is the most aggressive subtype of breast cancer. There has been rapid progress in targeted therapy and biomarker development to identify the optimal treatments for TNBC.To update recent developments, this article comprehensively reviews molecular classification and biomarkers of TNBC and targeted therapy…
Source: Clinical Breast CancerCategories: Latest Headlines, Oncologists2Tweet
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Mashup Score: 2Practice, Perceptions, and Prospects of Mammography Screening in Nigeria: Insights From a National Survey of Female Health Workers - 2 year(s) ago
Micro-abstractThe authors identified limited access to mammography screening as a major contributor of its poor uptake among Nigeria female health workers. Although most of the female doctors rarely refer eligible women for mammography screening currently, almost all were willing to refer along their line of duty going forward. Nigerian health workers recommended subsidized annual mammography…
Source: Clinical Breast CancerCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Breast pathologists have experimented with robotic dynamic microscopy and traditional whole slide imaging for making the primary diagnosis of breast lesions.1,2 These studies have shown encouraging results however the high cost of these setups has prevented their widespread use. Traditional whole slide imaging for telepathology for breast cases has been utilized for rapid breast care service.2…
Source: Clinical Breast CancerCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Characteristics, clinical differences and outcomes of breast cancer patients with negative or low HER2 expression - 2 year(s) ago
Background: High expression of HER2 receptor in Immunohistochemistry (IHC) sections or amplification of its gene in In Situ Hybridization (ISH) assays define a subset of breast cancers that have an aggressive natural history but respond to treatments blocking HER2. In contrast, patients with lower HER2 expression, not meeting the criteria for clinical positivity, are currently treated similarly…
Source: Clinical Breast CancerCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Isotope-only localisation for sentinel lymph node biopsy - medium-term oncological outcomes. - 2 year(s) ago
: Isotope and blue dye dual localisation in sentinel lymph node biopsy (SLNB) gives localisation rates of over 98% and is the recommended technique. However blue dye risks a range of adverse reactions. Since 2010, for clinically node negative disease, we have only used blue dye if there is no clear isotope signal at surgery.
Source: Clinical Breast CancerCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 2Margetuximab Versus Trastuzumab In Patients With Advanced Breast Cancer: A Cost-Effectiveness Analysis - 2 year(s) ago
: In the international, randomized, open-label, phase 3 study SOPHIA trial, margetuximab plus chemotherapy showed improved progression-free survival (PFS), and overall survival (OS) compared with trastuzumab plus chemotherapy. This study aimed to investigate whether margetuximab plus chemotherapy is cost-effective compared with trastuzumab plus chemotherapy in pretreated patients with…
Source: Clinical Breast CancerCategories: Latest Headlines, Oncologists1Tweet
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Mashup Score: 0
Magnetic seeds have emerged as an alternative to wires for localization of non-palpable breast lesions. The purpose of this study was to evaluate the utility of magnetic seeds compared to wires for pre-operative localization.
Source: Clinical Breast CancerCategories: Hematologists1, Latest HeadlinesTweet
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Mashup Score: 2An Update on the Molecular and Clinical Characteristics of Apocrine Carcinoma of the Breast - 2 year(s) ago
Apocrine carcinoma of the breast is a rare malignancy. According to 2019 WHO classification, apocrine cellular features and a characteristic steroid receptor profile (Estrogen receptor (ER)-negative and androgen receptor (AR)-positive) define apocrine carcinoma. Her-2/neu protein expression is reported in ∼30-50% of apocrine carcinomas, while NGS analysis showed frequent PIK3CA/PTEN/AKT and TP53…
Source: Clinical Breast CancerCategories: Hematologists1, Latest HeadlinesTweet
While we are chatting about ocular toxicity of cancer therapy, dropping this great review #BrownJC #ophtho https://t.co/sbhjOTlFPo