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Mashup Score: 0Regional variations in hepatocellular carcinoma incidence, routes to diagnosis, treatment and survival in England - British Journal of Cancer - 2 year(s) ago
Hepatocellular carcinoma (HCC) incidence, management and survival across England were examined to determine if geographical inequalities exist. 15,468 HCC cases diagnosed 2010–2016 were included. Age-standardised incidence rates, net survival and proportions receiving potentially curative treatment and presenting through each route to diagnosis adjusted for age at diagnosis, sex and area-based…
Source: British Journal of CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research - British Journal of Cancer - 2 year(s) ago
Prostate cancer is a global cancer burden and considerable effort has been made through the years to identify biomarkers for the disease. Approximately a decade ago, the potential of analysing extracellular vesicles in liquid biopsies started to be envisaged. This was the beginning of a new exciting area of research investigating the rich molecular treasure found in extracellular vesicles to…
Source: British Journal of CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research Read for free: https://t.co/kAPP92nwIe #Biomarkers #Prostatecancer https://t.co/QbN7T7y7DY
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Mashup Score: 0
Proton pump inhibitors (PPIs) are commonly used concomitant to cancer treatment and they induce gut microbiota changes. It is increasingly apparent that gut dysbiosis can reduce the effectiveness of immune checkpoint inhibitors (ICI). However, little is known about PPI effects on outcomes with ICIs, particularly in combination, ICI approaches. Post hoc, Cox proportional hazard analysis of phase…
Source: British Journal of CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
Efficacy of first-line atezolizumab combination therapy in patients with non-small cell lung cancer receiving proton pump inhibitors: post hoc analysis of IMpower150 | British Journal of Cancer https://t.co/K8VKvBCjN5
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Mashup Score: 0Artificial intelligence in oncology: current applications and future perspectives - British Journal of Cancer - 2 year(s) ago
Artificial intelligence (AI) is concretely reshaping the landscape and horizons of oncology, opening new important opportunities for improving the management of cancer patients. Analysing the AI-based devices that have already obtained the official approval by the Federal Drug Administration (FDA), here we show that cancer diagnostics is the oncology-related area in which AI is already entered…
Source: British Journal of CancerCategories: Future of Medicine, Latest HeadlinesTweet-
"One of the most promising expectancy for #AI is the possibility to integrate different and composite data derived from multi-omics approaches to oncologic patients." https://t.co/3VUDHJyAbJ #cancer #digitalhealth https://t.co/S56pXFUss1
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Mashup Score: 1
Active surveillance is an alternative to radical treatment for patients with low-risk prostate cancer, which could also benefit some patients with intermediate risk. We have investigated the use of miRNA in urinary extracellular vesicles to stratify these patients. NGS was performed to profile the miRNAs from small urinary extracellular vesicles in a cohort of 70 patients with prostate cancer…
Source: British Journal of CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Potential of miRNAs in urinary extracellular vesicles for management of active surveillance in prostate cancer patients Read for free: https://t.co/HzrIdyGMvj #Biomarkers #Prostatecancer https://t.co/ZjQ715r2Ey
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Mashup Score: 8Once weekly selinexor, carfilzomib and dexamethasone in carfilzomib non-refractory multiple myeloma patients - British Journal of Cancer - 2 year(s) ago
Proteasome inhibitors (PIs), including carfilzomib, potentiate the activity of selinexor, a novel, first-in-class, oral selective inhibitor of nuclear export (SINE) compound, in preclinical models of multiple myeloma (MM). The safety, efficacy, maximum-tolerated dose (MTD) and recommended phase 2 dose (RP2D) of selinexor (80 or 100 mg) + carfilzomib (56 or 70 mg/m2) + dexamethasone (40 mg) (XKd)…
Source: British Journal of CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
A new selinexor study,multiple issues summarised below🧵#mmsm https://t.co/QWHWO0qktZ ❌Once weekly selinexor,carfilzomib and dexamethasone in carfilzomib non-refractory multiple myeloma patients ❌ ✅ pts non-exposed to carfilzomib (only 3/32 pts received prior carfilzomib) https://t.co/Tk9vqFy5mV
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Mashup Score: 2At the dawn: cell-free DNA fragmentomics and gene regulation - British Journal of Cancer - 2 year(s) ago
Epigenetic mechanisms play instrumental roles in gene regulation during embryonic development and disease progression. However, it is challenging to non-invasively monitor the dynamics of epigenomes and related gene regulation at inaccessible human tissues, such as tumours, fetuses and transplanted organs. Circulating cell-free DNA (cfDNA) in peripheral blood provides a promising opportunity to…
Source: British Journal of CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @benbfly: Very nice and comprehensive review on cfDNA fragmentomics. Congrats @yapingliu ! https://t.co/tdLWQpgWfJ
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Mashup Score: 4Characterising 18F-fluciclovine uptake in breast cancer through the use of dynamic PET/CT imaging - British Journal of Cancer - 2 year(s) ago
18F-fluciclovine is a synthetic amino acid positron emission tomography (PET) radiotracer that is approved for use in prostate cancer. In this clinical study, we characterised the kinetic model best describing the uptake of 18F-fluciclovine in breast cancer and assessed differences in tracer kinetics and static parameters for different breast cancer receptor subtypes and tumour grades….
Source: British Journal of CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Characterising 18F-fluciclovine uptake in breast cancer through the use of dynamic PET/CT imaging Read for free: https://t.co/RpmKGzBdmt #Breastcancer #Cancerimaging #Translationalresearch https://t.co/t9ZIRirdpI
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Mashup Score: 1
Proton pump inhibitors (PPIs) are commonly used concomitant to cancer treatment and they induce gut microbiota changes. It is increasingly apparent that gut dysbiosis can reduce the effectiveness of immune checkpoint inhibitors (ICI). However, little is known about PPI effects on outcomes with ICIs, particularly in combination, ICI approaches. Post hoc, Cox proportional hazard analysis of phase…
Source: British Journal of CancerCategories: Hematologists1, Latest HeadlinesTweet-
PPI use is associated with worse survival in patients with advanced cancer treated with atezolizumab plus chemotherapy https://t.co/UN9NjTa3Lb
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Mashup Score: 0Risk-stratification of HPV-positive women with low-grade cytology by FAM19A4/miR124-2 methylation and HPV genotyping - British Journal of Cancer - 2 year(s) ago
The introduction of primary HPV screening has doubled the number of colposcopy referrals because of the direct referral of HPV-positive women with a borderline or mild dyskaryosis (BMD) cytology (ASC-US/LSIL) triage test. Further risk-stratification is warranted to improve the efficiency of HPV-based screening. This study evaluated the discriminative power of FAM19A4/miR124-2 methylation,…
Source: British Journal of CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Risk-stratification of HPV-positive women with low-grade cytology by FAM19A4/miR124-2 methylation and HPV genotyping Read for free: https://t.co/n9gF2encYM #Cervicalcancer #Diagnosticmarkers https://t.co/loi0ebQhDx
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Regional variations in hepatocellular carcinoma incidence, routes to diagnosis, treatment and survival in England Read for free: https://t.co/nVNgICE668 #Cancerepidemiology #Hepatocellularcarcinoma https://t.co/qYIyH9fLsO