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Mashup Score: 0Impact of different corticosteroids on severe community-acquired pneumonia: a systematic review and meta-analysis - 6 hour(s) ago
Objectives Randomised controlled trials (RCTs) have demonstrated conflicting results regarding the effects of corticosteroids on the treatment of severe community-acquired pneumonia (CAP). We aimed to investigate the efficacy and safety of different corticosteroids on patients who were hospitalised for severe CAP.Methods We performed a systematic search through PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus from inception to May 2023. The primary outcome was all-cause mortality. Data analysis was performed using a random-effects model.Results A total of 10 RCTs comprising 1962 patients were included. Corticosteroids were associated with a lower rate of all-cause mortality (risk ratio (RR), 0.70 (95% CI 0.54 to 0.90); I 2=0.00%). When stratified into different corticosteroid types, hydrocortisone was associated with an approximately 50% lower mortality risk (RR, 0.48 (95% CI 0.32 to 0.72); I2=0.00%). However, dexamethasone, methylprednisolone
Source: bmjopenrespres.bmj.comCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 0Homepage | BMJ Open Respiratory Research - 6 hour(s) ago
The open access companion journal to Thorax, publishing high quality papers in respiratory medicine, critical care, sleep medicine and related areas.
Source: bmjopenrespres.bmj.comCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 4Impact of COVID-19 on people with asthma: a mixed methods analysis from a UK wide survey - 2 day(s) ago
Introduction The impact of acute COVID-19 on people with asthma appears complex, being moderated by multiple interacting disease-specific, demographic and environmental factors. Research regarding longer-term effects in this group is limited. We aimed to assess impacts of COVID-19 and predictors of persistent symptoms, in people with asthma.Methods Using data from an online UK-wide survey of 4500 people with asthma (median age 50–59 years, 81% female), conducted in October 2020, we undertook a mixed methods analysis of the characteristics and experience of those reporting having had COVID-19.Results The COVID-19 group (n=471, 10.5%) reported increased inhaler use and worse asthma management, compared with those not reporting COVID-19, but did not differ by gender, ethnicity or household income. Among the COVID-19 group, 56.1% reported having long COVID, 20.2% were ‘unsure’. Those with long COVID were more likely than those without long COVID to describe: their breathing as worse or muc
Source: bmjopenrespres.bmj.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 2Impact of COVID-19 on people with asthma: a mixed methods analysis from a UK wide survey - 4 day(s) ago
Introduction The impact of acute COVID-19 on people with asthma appears complex, being moderated by multiple interacting disease-specific, demographic and environmental factors. Research regarding longer-term effects in this group is limited. We aimed to assess impacts of COVID-19 and predictors of persistent symptoms, in people with asthma.Methods Using data from an online UK-wide survey of 4500 people with asthma (median age 50–59 years, 81% female), conducted in October 2020, we undertook a mixed methods analysis of the characteristics and experience of those reporting having had COVID-19.Results The COVID-19 group (n=471, 10.5%) reported increased inhaler use and worse asthma management, compared with those not reporting COVID-19, but did not differ by gender, ethnicity or household income. Among the COVID-19 group, 56.1% reported having long COVID, 20.2% were ‘unsure’. Those with long COVID were more likely than those without long COVID to describe: their breathing as worse or muc
Source: bmjopenrespres.bmj.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 4Patient pathways for four major chronic respiratory diseases in England between 2008 and 2021 - 2 month(s) ago
Background Not all chronic diseases have clear pathways and time targets for diagnosis. We explored pathways and timings for four major chronic respiratory diseases in England. Methods Using deidentified electronic healthcare records from Clinical Practice Research Datalink Aurum linked to Hospital Episode Statistics, we derived cohorts of patients diagnosed with asthma, chronic obstructive pulmonary disease (COPD), ILD or bronchiectasis at three time periods (2008/2009, 2018/2019 and 2020/2021). We followed people 2 years before and 2 years after diagnosis, calculating the proportion of people who presented with symptoms, underwent diagnostic tests, were treated and consulted healthcare (primary or secondary) and calculated time intervals between events. We repeated analyses by socioeconomic status and geographical region. Results We descriptively studied patient pathways for 429 619 individuals across all time frames and diseases. Most people (>87%) had first evidence of diagnosis in
Source: bmjopenrespres.bmj.comCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 0Thoughtful prescription of inhaled medication has the potential to reduce inhaler-related greenhouse gas emissions by 85% - 2 month(s) ago
Introduction Both physicians and patients are increasingly aware of the environmental impacts of medication. The shift of treatment paradigm towards MART-treatment (Maintenance and Reliever Therapy) in asthma affects the treatment-related emissions. The carbon footprint of inhaled medication is also tied to the type of the device used. Today the most commonly used propellant-containing pressurised metered-dose inhalers (pMDIs) have a carbon footprint typically 20–40-fold higher than propellant-free dry powder inhalers (DPIs) and soft mist inhalers. Methods We analysed the carbon footprint of inhaled medications in Europe using published life cycle analyses of marketed inhalers and comprehensive 2020 European sales data. In addition, we give an estimate on treatment-related emissions of different treatment regimens on Global Initiative for Asthma (GINA) step 2. Results There is potential to reduce the carbon footprint of inhaled medications by 85% if DPIs are preferred over pMDIs. Emiss
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Mashup Score: 11Association between biomass exposure and COPD occurrence in Fez, Morocco: results from the BOLD study - 2 month(s) ago
Objective To investigate the association between biomass exposure and chronic obstructive pulmonary disease (COPD) in a representative sample of adults from the Moroccan population Methods A cross-sectional study was conducted in Fez as part of the Burden of Obstructive Lung Disease (BOLD) study, which included apparently healthy subjects aged 40 years and above. Biomass exposure was defined as self-report use of various biomass types for heating or cooking. The Wood Heating Exposure Index, and the Cooking Biomass Exposure Index were used to assess biomass exposure. Participants underwent post-bronchodilator spirometry and COPD was defined as having a forced expiratory volume in 1 s/forced vital capacity ratio <0.7. Descriptive, univariate and multivariable statistical analyses adjusting for potential confounders including age, sex, smoking, education level, Mokken scale (wealth index) and occupational dust exposure were performed for the general population and separately for men and w
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Mashup Score: 2BMJ Open Respiratory Research: 11 (1) - 6 month(s) ago
(2 May, 2024) Adrian P J Rabe, Wei J Loke, Danuta Kielar, Tamsin Morris, Vivian H Shih, Lynda Olinger, Mihaela G Musat, Zhiyi Lan, Sharada Harricharan, Olivia Fulton, Azeem Majeed, Liam G Heaney (2 May, 2024) Aline Stalder Siebeneichler, Desiree M Schumann, Meropi Karakioulaki, Nora Brachsler, Andrei M Darie, Leticia Grize, Thiago G Heck, Michael Tamm, Philipp Latzin, Daiana Stolz (1 May, 2024) Nikita Simms-Williams, Prasad Nagakumar, Rasiah Thayakaran, Nicola J Adderley, Richard Hotham, Adel H Mansur,
Source: bmjopenrespres.bmj.comCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 0Topic Collections | BMJ Open Respiratory Research - 6 month(s) ago
The open access companion journal to Thorax, publishing high quality papers in respiratory medicine, critical care, sleep medicine and related areas.
Source: bmjopenrespres.bmj.comCategories: General Medicine News, PulmonologyTweet
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Mashup Score: 0Top cited articles | BMJ Open Respiratory Research - 6 month(s) ago
The open access companion journal to Thorax, publishing high quality papers in respiratory medicine, critical care, sleep medicine and related areas.
Source: bmjopenrespres.bmj.comCategories: General Medicine News, PulmonologyTweet
Most read #BORR article in 2024 Impact of different corticosteroids on severe community-acquired pneumonia: a systematic review and meta-analysis https://t.co/OjPGHtJJfM #WinterBTS2024 #BORR #OpenAccess