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Mashup Score: 4Assessment of the efficacy and safety of tocilizumab in patients over 80 years old with giant cell arteritis - 4 year(s) ago
Objective To assess the efficacy and tolerance of tocilizumab (TCZ) in giant cell arteritis (GCA) patients over 80. Method GCA patients over 80 years old from the French Study Group for Large Vessel Vasculitis register who received TCZ were analyzed. Results Twenty-one GCA patients (median age 84 [81–90] years old, including nine over 85) received TCZ for the following nonexclusive reasons:…
Source: Arthritis Research & TherapyCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 0
Background A subcutaneous (SC) formulation of infliximab biosimilar CT-P13 is approved in Europe for the treatment of adult patients with rheumatoid arthritis (RA). It may offer improved efficacy versus intravenous (IV) infliximab formulations. Methods A network meta-regression was conducted using individual patient data from two randomised trials in patients with RA, which compared CT-P13 SC…
Source: Arthritis Research & TherapyCategories: Healthcare Professionals, Latest HeadlinesTweet-
Not in the US, but biosimilar infliximab (CT-P13) is being used subcutaneously in the EU and Canada. Analysis of 2 RCTs shows (compared to IV inflectra or remicade) SC CT-P13 greater DAS28-CRP, CDAI and SDAI response rates. https://t.co/prSVJ0BIdd
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Mashup Score: 1Deep learning for detection of radiographic sacroiliitis: achieving expert-level performance - 4 year(s) ago
Background Radiographs of the sacroiliac joints are commonly used for the diagnosis and classification of axial spondyloarthritis. The aim of this study was to develop and validate an artificial neural network for the detection of definite radiographic sacroiliitis as a manifestation of axial spondyloarthritis (axSpA). Methods Conventional radiographs of the sacroiliac joints obtained in two…
Source: Arthritis Research & TherapyCategories: Healthcare Professionals, Latest HeadlinesTweet-
Artificial intelligence study shows neural networks can be trained to detect radiographic sacroiliitis on pelvic Xrays and achieve expert-level detection of definite radiographic sacroiliitis & could improve diagnostic accuracy at non-specialised sites https://t.co/oLNzWjHjrw
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Mashup Score: 0Serious infections in ANCA-associated vasculitides in the biologic era: real-life data from a multicenter cohort of 162 patients - 4 year(s) ago
Background Serious infections (SI) are common in patients with ANCA-associated vasculitides (AAV) like granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Real-life data regarding their incidence and predisposing factors—after the introduction of B cell depleting agents—are limited while data quantifying the risk per treatment modality and year of the disease are missing….
Source: Arthritis Research & TherapyCategories: Healthcare Professionals, Latest HeadlinesTweet-
Retrospective study of 162 ANCA-Assoc Vasculitis patients (63% GPA, 37% MPA) - risk of serious infx was 7.5 per 100Pt-Yrs & was higher with cyclophosphamide that RTX induction. Risks for SIE:plasmapheresis dialysis & high BVAS in 1st year https://t.co/kAlz9aGQup
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Mashup Score: 0
Background Although the relationship between obesity and incident gout has been clarified, the influence of weight changes during the transition from early adulthood to midlife and the different weight change patterns in specific age ranges on the incidence of gout in later life remain unknown. Therefore, we aimed to investigate the association between weight change patterns across adulthood and…
Source: Arthritis Research & TherapyCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Maintaining non-obese weight and weight loss during adulthood is essential for the prevention and treatment of gout in adult life, according to research published in Arthritis Research & Therapy. https://t.co/ohDzqGGZaU
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Mashup Score: 4Risk factors for mortality of diffuse alveolar hemorrhage in systemic lupus erythematosus: a systematic review and meta-analysis - 4 year(s) ago
Background Diffuse alveolar hemorrhage (DAH) is a rare but life-threatening complication of systemic lupus erythematosus (SLE). The current knowledge of the prognostic factors for SLE-associated DAH is controversial. This meta-analysis was undertaken to investigate the relevant risk factors for mortality in SLE-associated DAH. Methods Studies were searched from PubMed, EMBASE, and Web of Science…
Source: Arthritis Research & TherapyCategories: Latest Headlines, PulmonologyTweet-
Risk factors for mortality of diffuse alveolar hemorrhage in systemic lupus erythematosus: a systematic review and meta-analysis: https://t.co/zn6HCdCNCR
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Mashup Score: 0Risk factors for mortality of diffuse alveolar hemorrhage in systemic lupus erythematosus: a systematic review and meta-analysis - 4 year(s) ago
Background Diffuse alveolar hemorrhage (DAH) is a rare but life-threatening complication of systemic lupus erythematosus (SLE). The current knowledge of the prognostic factors for SLE-associated DAH is controversial. This meta-analysis was undertaken to investigate the relevant risk factors for mortality in SLE-associated DAH. Methods Studies were searched from PubMed, EMBASE, and Web of Science…
Source: Arthritis Research & TherapyCategories: Latest Headlines, PulmonologyTweet-
Risk factors for mortality of diffuse alveolar hemorrhage in systemic lupus erythematosus: a systematic review and meta-analysis: https://t.co/zn6HCdCNCR
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Mashup Score: 6Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs - 4 year(s) ago
Background Biological disease-modifying anti-rheumatic drugs (bDMARDs) can be tapered in some rheumatoid arthritis (RA) patients in sustained remission. The purpose of this study was to assess the feasibility of building a model to estimate the individual flare probability in RA patients tapering bDMARDs using machine learning methods. Methods Longitudinal clinical data of RA patients on bDMARDs…
Source: Arthritis Research & TherapyCategories: Latest Headlines, RheumatologyTweet-
RT @DavidSi62640075: First advanced machine learning paper for flare prediction in RA. Take a look👍 https://t.co/d0J4D55moI
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Mashup Score: 2Cluster analysis of phenotypes of patients with Behçet’s syndrome: a large cohort study from a referral center in China - 4 year(s) ago
Introduction Behcet’s syndrome (BS) is a complex, heterogeneous disorder. However, classification of its subgroups is still debated. The purpose of this study was to investigate the clinical features and aggregation of patients with BS in China, based on manifestations and organ involvements. Methods This was a cross-sectional study of BS patients in Huadong Hospital of Fudan University between…
Source: Arthritis Research & TherapyCategories: Latest Headlines, RheumatologyTweet-
#ResearchHighlight | Different phenotypes identified for Behçet syndrome #vasculitis #Behcet Read the original research from @ArthritisRes here https://t.co/gBXIdDApdi and here https://t.co/XPQ825dcwq Read our #news story here https://t.co/jw5Zo1awip
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Mashup Score: 0Arthritis Research & Therapy - 4 year(s) ago
One of the world’s leading journals in the field of rheumatology, Arthritis Research & Therapy covers a broad range of autoimmune rheumatic and …
Source: Arthritis Research & TherapyCategories: Latest Headlines, RheumatologyTweet-
📢📢Our timely topical collection on 'Digital Rheumatology' is still open for submissions - send in your Original Research, Review, Letter or Commentary before 31st March! More info 👉 https://t.co/0xKad5dKsD #rheum https://t.co/LDmHdwWuLk
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Real world study of 21 GCA patients over age 80 yrs taking tocilizumab. (for GC-sparing in 14, relapsing Dz in 8, severity in 4, DMARD failure in 4). 8 [2–21] months post-TCZ, 67% were off GCs. AE included 4 Hi Chol, 3 SIE, 2 cytopenia, 1 hi LFTs https://t.co/ER0ROQw4ma