Small speckles, big impact
Nature Reviews Cancer – In this study, Alexander et al. find that HIF2α regulates speckle–DNA associations to fine-tune the expression of a subset of its target genes, and demonstrate…
Nature Reviews Cancer – In this study, Alexander et al. find that HIF2α regulates speckle–DNA associations to fine-tune the expression of a subset of its target genes, and demonstrate…
Patients with relapsed ovarian cancer who had germline or somatic BRCA mutations saw greater OS with olaparib, according to data from the LIGHT trial.
Diagnosed with multiple myeloma in 2004, Vicki Jones has lived with her cancer for more than 20 years thanks to chemotherapy and immunotherapy.
Datopotamab deruxtecan approaches approval in Europe as an option for patients with previously treated hormone receptor–positive breast cancer.
Nature Medicine – Using national registry data from Denmark, 30 maternal diagnoses linked to offspring autism were identified with most associations attributable to family-level factors…
Nature Reviews Cancer – Pet dogs with cancer facilitate comparative oncology, enhancing translational research. In this Comment, Lenz and Atherton highlight comparative oncology successes,…
Nature Reviews Immunology – A preprint by Makris et al. shows that podoplanin is a key regulator of the functions of fibroblastic reticular cells in…
Nature Reviews Immunology – Besides its beneficial effects against infection, trained immunity has recently been implicated in inflammation-related disorders and is being exploited in cancer…
Panelists discuss how myelofibrosis progresses from its molecular and genetic origins through various clinical manifestations, ultimately informing the development of targeted therapeutic approaches for this…
Panelists discuss Melinda’s experience with her lung cancer diagnosis, including her symptoms, diagnostic tests (such as imaging and blood work), and the progression of her…
Communications Earth & Environment – The increase in lead contamination 2150 years before present affected marine and terrestrial environments of the Aegean region. It coincided…