Single-cell systems pharmacology identifies development-driven drug response and combination therapy in B cell acute lymphoblastic leukemia
Network-based analyses of single-cell transcriptomes delineate B cell differentiation and its impact on leukemia drug sensitivity. Huang et al. uncover a correlation between developmental states and asparaginase response in B cell acute lymphoblastic leukemia, highlighting intra-leukemia heterogeneity. Targeting BCL2 enhances asparaginase efficacy, suggesting a systems pharmacology approach to rational combination therapy design.