A growing body of evidence indicates sex differences in the clinical outcomes of coronavirus disease 2019 (COVID-19)1–5. However, whether immune responses against SARS-CoV-2 differ between sexes, and whether such differences explain male susceptibility to COVID-19, is currently unknown. In this study, we examined sex differences in viral loads, SARS-CoV-2-specific antibody titers, plasma…
npj Cardiovascular Health – Polygenic risk scores improve CAD risk prediction in individuals at borderline and intermediate clinical risk
Medical and Population Genetics PrimerApril 17, 2025Broad Institute of MIT and HarvardSarah UrbutMassachusetts General Hospital;Broad InstituteSetting up a B…
Cardiovascular disease (CVD) is a life-changing and often frightening condition—one that weighs heavily on the global South Asian community. Many South Asians either have been…
Cardiovascular disease (CVD) is a life-changing and often frightening condition—one that weighs heavily on the global South Asian community. Many South Asians either have been…
Large-scale genetic association studies have identified thousands of trait-associated risk loci, establishing the polygenic basis for common complex traits and diseases. Although prior studies suggest…
HIP is greater for somatic mutations in pre-defined CHIP driver genes other than DNMT3A (referred to as non-DNMT3A CHIP). We sought to assess the prospective…
HIP is greater for somatic mutations in pre-defined CHIP driver genes other than DNMT3A (referred to as non-DNMT3A CHIP). We sought to assess the prospective…
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