Roving Eye and Head in a Patient With Genetic Creutzfeldt-Jakob Disease | Neurology
An 81-year-old woman was diagnosed with genetic Creutzfeldt-Jakob disease based on dementia, cortical ribboning in diffusion-weighted MRI, and V180I mutation in the prion protein gene. The CSF real-time quaking-induced conversion test was negative. She developed akinetic mutism, displaying periodic alternating gaze deviation synchronized with head turning persisting for several hours after 4 years of onset (Video 1). Progressing into a coma with spontaneous eye opening, she exhibited an absent menace