Maruyama et al. provide evidence from mouse experiments that fecal single-stranded RNA (ssRNA) is sensed in the gut by the cation channel Piezo1. They show that ssRNA-stimulated Piezo1 is involved in peristalsis and gut serotonin synthesis and reduced bone mass. The ssRNA-Piezo1 axis reported could be a prophylactic target for treatment of bone and gut disorders, including the side effects of…
A single taste receptor initiates our reactions to both sugars and artificial sweeteners, triggering a signaling process that drives our intense attraction to sweet foods.…
Recombination-aware evolutionary analyses of the entire genomes of SARS-CoV-1-like and SARS-CoV-2-like viruses indicate that SARS-CoV-1 and SARS-CoV-2 descend from bat coronaviruses that circulated as recently…
m6A is a potent inducer of ribosome stalling and collisions that trigger YTHDF-mediated mRNA degradation, a process that highlights the ribosome as a critical sensor…
Cell Symposia: Towards sustainable agriculture: Genomics, bioengineering, and smart technologies
The CCR5delta32 deletion arose on a pre-existing haplotype of 84 variants over 6,700 years ago in the Western Steppe. Positive selection drove it to high…
To combat snake bites from diverse species, this work identifies broadly neutralizing antibodies from a donor hyperimmune to snake venom, and it demonstrates that a…
Lactate production in innate immune cells can regulate both acute and long-term inflammatory responses. By modifying histone lactylation, lactate production leads to long-term epigenetic memory…
Insulin gene variation predisposes individuals to type 1 diabetes (T1D). We report a new mechanism of genetic protection from T1D in which insulin mRNA with…
This study uncovers the molecular mechanism of LAG3 activation upon ligand engagement and its regulation by non-degradative polyubiquitination within the tumor microenvironment. The findings highlight…
Precision proteogenomics analysis of 1,064 cancer patients across ten cancer types unveils the ways in which rare and common germline variants shape the cancer proteome;…
