Rapid Response of Neutrophils Determined by Shortest Differentiation Trajectories and Absence of Self-Renewal in committed Progenitors
Despite substantial advances in our understanding of hematopoietic stem cell self-renewal and differentiation, the underlying mechanisms have remained elusive. Neutrophils are the primary and rapid responders during infections of innate immunity and can quickly generate an enormous number of mature neutrophils for immune defense. The underlying mechanisms have been investigated but still present conflicts. Our previous study clearly redefined progenitors and reformed the hierarchy of hematopoiesis. Here, we aim to reveal the underlying mechanisms and provide a new interpretation of immune phenomena. We describe the conversion of the cell cycle from differentiation to proliferation in peripheral hematopoiesis. The differentiation hematopoietic progenitor cells (HPCs) were maintained in cell cycle G1 phase, controlled by the DNA replication of cell cycle. DNA replication switched and controlled the progenitor status from differentiation to proliferation. Our study showed that the initial