Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension | NEJM
Original Article from The New England Journal of Medicine — Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension
Original Article from The New England Journal of Medicine — Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension
The subcutaneous implantable cardioverter–defibrillator (ICD) is associated with fewer lead-related complications than a transvenous ICD; however, the subcutaneous ICD cannot provide bradycardia an…
This feature about an attending preparing for her upcoming week of service offers a case vignette accompanied by two essays, one supporting visiting patients early…
Quick Take Video Summary from The New England Journal of Medicine — Olezarsen for Hypertriglyceridemia
Standard treatment with neoadjuvant nivolumab plus chemotherapy significantly improves outcomes in patients with resectable non–small-cell lung cancer (NSCLC). Perioperative treatment (i.e., neoadj…
Many persons with chronic obstructive pulmonary disease (COPD) or asthma have not received a diagnosis, so their respiratory symptoms remain largely untreated. We used a…
Reducing the levels of triglycerides and triglyceride-rich lipoproteins remains an unmet clinical need. Olezarsen is an antisense oligonucleotide targeting messenger RNA for apolipoprotein C-III (A…
Adjustment for race is discouraged in lung-function testing, but the implications of adopting race-neutral equations have not been comprehensively quantified. We obtained longitudinal data from…
Dupilumab, a fully human monoclonal antibody that blocks the shared receptor component for interleukin-4 and interleukin-13, key and central drivers of type 2 inflammation, has…
Nivolumab plus ipilimumab or nivolumab alone resulted in longer progression-free and overall survival than ipilimumab alone in a trial involving patients with advanced melanoma. We…
Without effective treatment, pulmonary arterial hypertension results in high morbidity and mortality. This review discusses the pathogenesis of the disorder, the thorough clinical evaluation requir…