PI3K/Akt signaling promotes metabolic adaptation to ONC201-mediated disruption of mitochondrial energy homeostasis in diffuse intrinsic pontine glioma, highlighting the utility of a combination treatment strategy using ONC201 and the PI3K/Akt inhibitor paxalisib.
Convergence Science | Cancer Research | American Association for Cancer Research .aacrcontent { display: flex; flex-direction: row; justify-content: space-between; align-items: stretch; } .intro { margin-top:…
Abstract. Pancreatic cancer prevalence increases with age, and disease prognosis is poorer in older individuals. The increased prevalence is driven, undoubtedly, by the multistep accumulation…
Aged pancreatic fibroblasts secrete GDF-15 and activate AKT signaling to promote pancreatic cancer growth, highlighting the critical role of aging-mediated changes in the pancreatic cancer…
Abstract. Tumor-associated tertiary lymphoid structures (TLS) have been associated with favorable clinical outcomes and response to immune checkpoint inhibitors in many cancer types, including non–small…
Abstract. The intersection of precision medicine and artificial intelligence (AI) holds profound implications for cancer treatment, with the potential to significantly advance our understanding of…
Abstract. Metastasis arises from cancer-cell intrinsic adaptations and permissive tumor microenvironments (TME) that are distinct across different organs. Deciphering the mechanisms underpinning organotropism could provide…
2023 Covers | Cancer Research | American Association for Cancer Research #aacr_embed_signup .aacr-field-group.input-group ul{list-style: none;} #aacr_embed_signup .aacr-field-group.input-group ul li{display: inline-block; width: fit-content; padding: 20px;} .inputsection…
Cancer Research | 84 | 8_Supplement | April 2024
Scientific publishing is a cornerstone of disseminating knowledge. One caveat of scientific publishing is that at any one time it is biased toward certain topics…
Cancer Research | 84 | 8 | April 2024
