Type 2 diabetes mellitus (T2DM) is one of the greatest health crises of our time and its prevalence is projected to increase by >50% globally by 2045. Currently, 10 classes of drugs are approved by the US Food and Drug Administration for the treatment of T2DM. Drugs in development for T2DM must show meaningful reductions in glycaemic parameters as well as cardiovascular safety. Results from an…
Nature Metabolism – Veniant et al. report here on a GIPR antagonist conjugated to GLP-1 analogues that reduces body weight and improves metabolic markers in…
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Nature – Regulators have identified around 30 cases of cancer linked to this blockbuster treatment. But is CAR T to blame? The hunt is on…
European Journal of Clinical Nutrition – Olive oil consumption is associated with lower cancer, cardiovascular and all-cause mortality among Italian adults: prospective results from the…
Nature Immunology – Jakubzick and colleagues show that interstitial macrophages across various tissues display similar coordinated chemokine signatures in humans and mice.
Nature Communications – Influenza B viruses are linked to significant morbidity and mortality, and yet their immunobiology is comparatively poorly understood. Here Menon et al…
npj Parkinson’s Disease – Lysosomal genes contribute to Parkinson’s disease near agriculture with high intensity pesticide use
Nature – It can be hard when junior scientists feel unsupported. Nature asked three scientists for their advice on how to respond.
Nature – Quantitative multimodal 3D reconstruction of human pancreatic tissue at single-cell resolution reveals a high burden of multifocal, genetically heterogeneous pancreatic intraepithelial…
Nature Medicine – In a randomized clinical trial, alerts based on the detection of abnormalities in electrocardiograms using a deep learning algorithm reduced all-cause mortality…
