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In the article Bone Tumors – Differential diagnosis we discuss a systematic approach to the differential diagnosis of bone tumors and tumor-like lesions. In this article we will discuss the differential diagnosis of well-defined osteolytic bone tumors and tumor-like lesions. Abbreviations used: On the left the most common well-defined bone tumors and tumor-like lesions. These lesions are sometimes referred to as benign cystic lesions, which is a misnomer since most of them are not cystic, except for SBC