Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer
Di Chiaro et al. assign distinct transcriptional and functional programs to intratumor morphological variants that coexist in all pancreatic ductal adenocarcinomas (PDAC), providing a valuable resource for translational studies. These variants impose distinct local subversions of the extracellular matrix that in turn affect tumor invasive properties and specifically neural infiltration.