Circulating tumor cells (CTCs) are regarded as “seeds” of tumor metastasis. By dissecting the interaction between CTCs and immunocytes at single-cell scale, Liu et al. propose that CTCs escape immunosurveillance from NK cells by engaging the immune checkpoint HLA-E:CD94-NKG2A. Interrupting the checkpoint efficiently prevents tumor metastasis via the blood circulation.
Tricarboxylic acid (TCA) cycle metabolites have been implicated in modulating signalling pathways in immune cells. Notable examples include succinate and itaconate, which have pro- and…
We report on the relationship between leukocyte telomere length (LTL), genetics, and environmental factors in ethnically diverse Africans. LTL is longer in African ancestry individuals…
STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all…
OA was generally considered as a non-inflammatory disease dominated by articular cartilage degeneration. However, the role of synovitis in OA pathogenesis has received increasing attention.…
Polyamines – putrescine, spermidine, and spermine – are widely distributed aliphatic compounds known to regulate important biological processes in prokaryotic and eukaryotic cells. Therefore, spermidine…
The intestinal epithelium fulfills important physiological functions and forms a physical barrier to the intestinal lumen. Barrier function is regulated by several pathways, and its…
DNA methylation is increasingly used as a biomarker of health and associates with BMI. Do et al. constructed an epigenetic BMI score and observed differential metabolic…
Despite the relative noisiness of polygenic indexes (PGIs), some commercial firms will use them. We offer a simple model, rooted in economic theory, to show…
A massively parallel reporter assay (MPRA) characterizes the potential for histone post-translational modifications (i.e., histone quantitative trait loci [hQTLs]) to modulate regulatory activity and uncovers…
The T allele at the ERAP2 SNP rs2549794 has been suggested as deleterious during the Black Death. We have found that the T allele is…
