High-Dose Oral Vitamin A Before HCT May Reduce GVHD in Children | ASH Clinical News | American Society of Hematology
Katie Robinson is a medical writer based in New York. Compared with placebo, a high dose of oral vitamin A given before a hematopoietic cell transplant (HCT) did not reduce the incidence of acute graft-versus-host disease (GVHD) in children. However, the results of a phase II study published in Blood found that high-dose vitamin A given pre-HCT reduced chronic GVHD in this population and reduced acute gastrointestinal (GI) GVHD in an as-treated analysis. 1 Vitamin A maintains immune homeostasis in the