Guarding the Endothelium: SOX17’s Crucial Role in Pulmonary Hypertension
Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease that features loss of distal capillary vessels and obstructive remodeling of the pulmonary arterioles that results in progressive right heart failure and functional decline (1). PAH remains incurable, with a high mortality rate of ∼40%. Current treatments do not specifically target pulmonary vascular remodeling and right heart failure; thus, investigating molecular mechanisms that regulate these responses paves the way for
