Genomic landscape of Down syndrome–associated acute lymphoblastic leukemia
Key Points. Using whole-genome sequencing and RNA-seq, we characterized the genomic landscape of 295 DS-ALL cases and identified 15 distinct subtypes.DS-ALL exh
Key Points. Using whole-genome sequencing and RNA-seq, we characterized the genomic landscape of 295 DS-ALL cases and identified 15 distinct subtypes.DS-ALL exh
In this issue of Blood, Leung et al1 present preclinical findings demonstrating the potential of neoantigen-specific T cells to recognize acute myeloid leu
Fernandez Sanchez and colleagues review the complex interaction of the intestinal microbiome and hematopoiesis. Intestinal microbiotas influence blood cell
In this issue of Blood, Dou et al1 reveal a decisive role for hematopoietic lymphocyte adapter protein (LNK) deficiency in promoting eosinophilia, systemic
In this issue of Blood, Leung et al1 present preclinical findings demonstrating the potential of neoantigen-specific T cells to recognize acute myeloid leu
Neoantigens arising from recurrent AML mutations are immunogenic and represent novel immunotherapeutic targets.IDH2R140Q-specific T cells can selectively e
Individuals with MBL who have a high-risk epigenetic/immunogenetic signature show significant risk of progression to CLL requiring therapy.The signature im
High expression levels of miR-145 in plasma are robustly associated with decreased risk of future incident VTE in a population-based study.miR-145 has the
In this issue of Blood, Morelli et al1 report that high plasma levels of miR-145 are associated with decreased risk of incident venous thromboembolism (VTE
In this issue of Blood, Abdelbaky and colleagues report the development of a combined epigenetic and immunogenetic signature to study individuals with high
Tisagenlecleucel responses in patients with r/r FL remain highly durable a year after primary analysis; no new safety signals were observed.Low levels of L